On August 18, 2021, the Board of Directors of Design Therapeutics, Inc. appointed Julie Burgess as the Company’s Chief Accounting Officer and principal accounting officer, effective upon the date she commences employment with the Company. Upon the Effective Date, which is expected to be September 13, 2021, Dawn Giangiulio, the Company’s Controller and interim principal accounting officer, will discontinue serving as the Company’s interim principal accounting officer. Ms. Burgess’s appointment will not affect Ms. Giangiulio’s status as the Company’s Controller. Ms. Burgess has served as Senior Vice President, Finance at Otonomy, Inc. since April 2021, and before that served as Otonomy’s Vice President, Finance and Administration from January 2014 to April 2021.