The data showed that SCB-2019 (CpG 1018/Alum) elicited superior levels of neutralizing antibodies against the Omicron BA.5 subvariant, the dominant SARS-CoV-2 variant circulating globally today, when administered as a heterologous third dose in participants
'Omicron BA.5 is globally dominant today, representing over 90% of circulating strains, and evidence indicates that it has some degree of immune escape,' said Dr.
A booster dose of SCB-2019 (CpG 1018/Alum) in participants
The Omicron BA.5 heterologous booster responses are consistent with prior data from this Phase 3 study (LINK), which showed a similarly superior response against the SARS-CoV-2 prototype, Omicron BA.1 and Omicron BA.2 for SCB-2019 (CpG 1018/Alum), relative to inactivated vaccine. They are also consistent with previously released results demonstrating the strong SCB-2019 (CpG 1018/Alum)-elicited immune responses against Omicron BA.5 in other populations, including those receiving a homologous third dose of SCB-2019 (CpG 1018/Alum) and those
These results are part of a Phase 3, double-blind, randomized and controlled study that is evaluating the safety and immunogenicity of SCB-2019 (CpG 1018/Alum) administered as a booster dose in individuals
Clover remains focused on completing regulatory submissions to the
About SCB-2019 (CpG 1018/Alum)
Employing the Trimer-Tag technology platform, Clover developed the SCB-2019 antigen, a stabilized trimeric form of the S-protein (referred to as S-Trimer) based on the original strain of the SARS-CoV-2 virus. Clover created its COVID-19 vaccine candidate by combining SCB-2019 with
About
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