e-Therapeutics plc

('e-Therapeutics' or 'the Company')

Issue of Equity and Directors' Shareholdings

21 September 2016, Oxford and Newcastle, UK:e-Therapeutics plc (AIM: ETX), the drug discovery company, announces the issue, pursuant to the Company's offer for the issued and to be issued share capital of Searchbolt Limited ('Searchbolt') ('the Offer'), of 8,864 new ordinary shares.

Under the Offer certain of the consideration was withheld pending the satisfaction of certain conditions. Those conditions have now been satisfied and the relevant retention is now payable. Certain of the sellers of Searchbolt shares elected to receive a total of 8,864 ordinary shares in e-Therapeutics in satisfaction of some or all of their entitlement to such retention. The new ordinary shares were allotted on 21 September 2016 at a price of 14.55 pence per share, this being the average of the closing mid-market price on the 30 business days ending on the day before the announcement of the Offer.

Sean Nicolson, a director of e-Therapeutics and a former shareholder in Searchbolt Limited, elected to take the full share alternative entitlement in e-Therapeutics shares. The number of shares allotted to Mr Nicolson on 21 September 2016 and his resultant total interest in e-Therapeutics shares following this allotment are shown below.

Director

Shares allotted

21 September 2016

Ordinary shares held following allotment (% of issued share capital)

Options over ordinary shares held (% of issued share capital)

Sean Nicolson

2,166

140,573 (0.05%)

-

Application has been made to admit the 8,864 new ordinary shares to trading on AIM and dealings in the new ordinary shares are expected to commence on 28 September 2016.

Following admission the number of ordinary shares in issue in the Company will be 268,347,921. This figure may be used by shareholders as the denominator for the calculations by which they will determine whether they are required to notify their interest in, or a change to their interest in, e-Therapeutics plc under the Financial Conduct Authority's Disclosure and Transparency Rules.

Contacts:

e-Therapeutics plc

Iain Ross, Chairman

Steve Medlicott, Finance Director

Tel: +44 (0) 1993 883 125

www.etherapeutics.co.uk

Numis Securities Limited

Michael Meade / Freddie Barnfield (Corporate Finance)

James Black (Corporate Broking)

Tel: +44 (0) 207 260 1000

www.numis.com

Instinctif Partners

Melanie Toyne Sewell / Jayne Crook / Emma Barlow

Tel: +44 (0) 207 457 2020

Email:e-therapeutics@instinctif.com

About e-Therapeutics plc

e-Therapeutics (AIM: ETX) is a drug discovery company with a proprietary discovery platform based on advances in network pharmacology and chemical biology. The Company is applying its platform to the discovery of new drug candidates. The therapeutic focus of the Company's activity is in immuno-oncology, addressing drug resistance in targeted cancer therapies and anti-infectives. The platform is highly productive, yielding multiple potent and selective molecules at a much higher rate and more quickly than is reported for conventional drug discovery.

e-Therapeutics has a variety of preclinical stage assets, including ETS2300, telomerase inhibition in anti-cancer; ETS3100, small molecule anti-TNFα; ETS2400, Hedgehog pathway inhibition and ETS5200, broad spectrum antivirals. The Company has recently completed a phase IIb clinical trial for ETS6103, a drug to treat major depressive disorder.

The Company is fully funded to advance its drug discovery programmes. It is based in Oxford and Newcastle, UK. For more information, visitwww.etherapeutics.co.uk.

e-Therapeutics plc published this content on 21 September 2016 and is solely responsible for the information contained herein.
Distributed by Public, unedited and unaltered, on 21 September 2016 15:28:06 UTC.

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