e-Therapeutics plc ('e-Therapeutics' or the 'Company') Progress in ETS2101 Phase Ib Study Oxford and Newcastle, UK, 21 May 2015 - e-Therapeutics plc (AIM: ETX) announces today that the first patient has been enrolled into its phase 1b programme for its cancer drug, ETS2101. The first patient received the initial dose on 19 May and will be included in the cohort investigating the safety, tolerability and anti-tumour activity of ETS2101 in patients with newly-diagnosed hepatocellular carcinoma (HCC), in combination with standard of care, sorafenib.

As part of this programme of work, in addition to newly-diagnosed HCC, e- Therapeutics will be investigating ETS2101 in combination with the standard of care for patients with newly-diagnosed pancreatic cancer (gemcitabine plus nab- paclitaxel), and as a monotherapy in patients with primary HCC or pancreatic cancer who have relapsed or refractory disease.

Steve Self, Development director of e-Therapeutics said:

"This marks an important milestone for ETS2101 as its development programme begins to explore aspects of this agent's activity in specific cancer indications, alongside further aspects of dosing and safety. This study is directed towards further clinical development of the compound and will inform our understanding of the drug in this therapeutic area."
ETS2101 was discovered in the context of cancer by e-Therapeutics through the molecule's high impact in networks mediating programmed cell death in cancer cells. In the laboratory, it showed potent killing of all cancer cell-types tested. To date, it has been evaluated in three Phase I trials, which showed: evidence indicative of the
halting of tumour progression; tumour regression according to RECIST criteria in one case; concentrations of the drug in circulating plasma more than ten times that
required to kill cancer cells in vitro; and the potential viability of an oral dose form.
The Phase Ib trial commencing now is designed to explore the safety, dosing and activity of ETS2101 both in monotherapy and in combination with standard of care treatment in HCC and pancreatic cancer.
-Ends-

Contacts: e-Therapeutics plc

Malcolm Young, CEO / Steve Medlicott, Finance Director

Tel: +44 (0)1993 883 125 www.etherapeutics.co.uk

N+1 Singer

Aubrey Powell / Jen Boorer Tel: +44 (0) 20 7496 3000 www.n1singer.com

Instinctif Partners

Melanie Toyne Sewell / Jayne Crook

Tel: +44 (0) 20 7457 2020

Email: e-therapeutics@instinctif.com

About e-Therapeutics plc

e-Therapeutics is an AIM-quoted drug discovery and development company with a proprietary platform in network pharmacology, an innovative new approach to drug discovery based on advances in network science and chemical biology. The Company's discovery and development activity is currently focused in cancer and disorders of the nervous system.

e-Therapeutics is based at sites in Oxford and Newcastle, UK. For more information about the

Company, please visit www.etherapeutics.co.uk.

distributed by