ADA Update

July 1, 2021

Not for promotional use

1

Introduction

Mike Mason, President, Lilly Diabetes

SURPASS Overview

Jeff Emmick, M.D., Ph.D., Vice President, Lilly

Diabetes Product Development

Early Phase Diabetes

Ruth Gimeno, Ph.D., Vice President, Lilly

Diabetes and Metabolic Research

Q&A

Not for promotional use

2

SAFE HARBOR PROVISION

This presentation contains forward-looking statements that are based on management's current expectations, but actual results may differ materially due to various factors. The company's results may be affected by factors including, but not limited to, the risks and uncertainties in pharmaceutical research and development; competitive developments; regulatory actions; the extent and duration of the effects of the COVID-19 pandemic; litigation and investigations; business development transactions; economic conditions; and changes in laws and regulations, including health care reform.

For additional information about the factors that may affect the company's business and could cause actual results to differ materially, please see the company's latest Form 10-K, subsequent 10-Q, and 8-K filed with the Securities and Exchange Commission.

The company undertakes no duty to update forward-looking statements

Not for promotional use

2021 LILLY ADA UPDATE

3

MOMENTUM IN DIABETES BUSINESS

SIGNIFICANT GROWTH IN THE PAST DECADE WITH DIVERSE OPPORTUNITIES IN THE FUTURE

2010-2020

GROWTH BEYOND INSULIN

DIABETES WORLDWIDE REVENUE HAS MORE THAN TRIPLED ~$12B

~$4B

2010

2020

®

®

®

®

®

Humalog

Humulin

Trulicity

Jardiance

Basaglar

Other

2020-2030

DIABETES & RELATED METABOLIC DISORDERS

Trulicity: Additional doses and cardiovascular outcomes reinforce market leadership and are catalysts for continued class growth

Jardiance: Continued market leadership in growing SGLT-2 inhibitor class with potential NILEX opportunities in HFrEF, HFpEF and CKD

Insulin: Connected care potential to improve patient outcomes

Tirzepatide: Potential paradigm changing treatment in type 2 diabetes with expanding NILEX opportunities in obesity and other metabolic disorders

Early-stagepipeline: Opportunities across classes including basal insulin FC, GGG and oral incretins

Note: Jardiance and Basaglar are part of the Boehringer Ingelheim (BI) and Lilly Alliance and BI holds the marketing authorization for Jardiance; NILEX = line extension; HFrEF = heart failure with reduced ejection fraction; HFpEF = heart failure with preserved

4

ejection fraction; CKD = chronic kidney disease; GGG = GIP, GLP-1and Glucagon triple receptor agonist

2021 LILLY ADA UPDATE

Not for promotional use

TIRZEPATIDE SURPASS PROGAM

OVERVIEW & NEXT STEPS

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Eli Lilly and Company published this content on 01 July 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 01 July 2021 14:52:25 UTC.