Eli Lilly and Company announced that enrollment is now open for the CHALLENGE-MIG clinical trial, the first and only head-to-head trial comparing two anti-calcitonin gene-related peptide (CGRP) medicines for the preventive treatment of episodic migraine in adults. The study is evaluating once-monthly Emgality (galcanezumab-gnlm) injection compared to Nurtec ODT (rimegepant), a tablet patients take every other day, on patient-centric measures, including reductions in monthly migraine headache days and quality of life improvement. While Nurtec ODT and Emgality are both medications that target CGRP, because Emgality is a?monoclonal antibody (mAb) that binds to CGRP (a protein found in the brain thought to play a key role in migraine), it works differently than gepants like Nurtec ODT, that bind to and block the CGRP receptor.?Emgality is the only CGRP medication with =50%, =75% and 100% reductions of monthly migraine headache days in its label for people with episodic migraine experiencing 4 to 14 migraine headache days per month. Lilly's CHALLENGE-MIG study aims to deepen the understanding of CGRP monoclonal antibodies (mAbs) compared to oral gepants in the preventive treatment of migraine and answer important questions that will help physicians and patients make informed treatment decisions. The CHALLENGE-MIG clinical trial is expected to enroll approximately 700 adults across the U.S. with episodic migraine, and individual participation in the study can last up to 6 months. For more information about the CHALLENGE-MIG trial, contact The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979). Information about the CHALLENGE-MIG study is also available at the Lilly booth at the American Headache Society's annual education symposium taking place in Scottsdale, AZ, November 18-21, 2021.