Item 1.01 Entry into a Material Definitive Agreement.

On August 11, 2021, Epizyme, Inc., a Delaware corporation (the "Company"), entered into a Fifth Amendment to Lease (the "Fifth Amendment") with ARE-TECH Square, LLC, a Delaware limited liability company (the "Landlord"). The Fifth Amendment amends that certain Lease Agreement dated June 15, 2012, as amended (the "Lease"), and is effective as of August 11, 2021. Under the Fifth Amendment, the Company extended the term of the Lease for the Company's headquarters in Cambridge, Massachusetts through November 30, 2024.

Under the Fifth Amendment, the Company will continue to pay the Landlord the current monthly base rent amount contemplated by the Lease through November 30, 2022, with an increase commencing on December 1, 2022 and adjusting the monthly base rent amount to approximately $377,000 and an increase commencing on December 1, 2023 and adjusting the monthly base rent amount to approximately $388,000 through November 30, 2024. In addition, under the Fifth Amendment, the Landlord will provide the Company with a tenant improvement allowance of up to approximately $430,000 if requested by the Company by August 11, 2022, subject to specified terms and conditions.

Except as amended by the Fifth Amendment, the Lease remains in full force and effect.

The foregoing description of the Fifth Amendment does not purport to be complete and is subject to, and qualified in its entirety by, the full text of the Fifth Amendment, a copy of which is filed as an exhibit to this Form 8-K.

Item 9.01 Financial Statements and Exhibits






(d) Exhibits




10.1      Fifth Amendment to Lease dated as of August 11, 2021, by and between the
        Company and ARE-TECH Square, LLC

104     Cover Page Interactive Data File (embedded within the inline XBRL
        document)

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