Item 5.07 Submission of Matters to a Vote of Security Holders

Epizyme, Inc., a Delaware corporation (the "Company"), held its Annual Meeting of Stockholders on June 11, 2021. The following is a summary of the matters voted on at that meeting.





a)  The stockholders of the Company elected Grant Bogle, Kevin T. Conroy, and
    Carl Goldfischer, M.D. as Class II directors, each for a three-year term
    ending at the annual meeting of stockholders to be held in 2024. The results
    of the stockholders' vote with respect to the election of the Class II
    directors were as follows:




                                        Votes       Broker
Name                     Votes For     Withheld    Non-Votes
Grant Bogle              74,864,792    737,607     8,106,611

Kevin T. Conroy 38,635,442 36,966,957 8,106,611 Carl Goldfischer, M.D. 67,855,181 7,747,218 8,106,611

b) The stockholders of the Company ratified the selection of Ernst & Young LLP


    as the Company's independent registered public accounting firm for the fiscal
    year ending December 31, 2021. The results of the stockholders' vote with
    respect to such ratification were as follows:




                                  Broker
   For       Against   Abstain   Non-Votes
83,587,365   43,662    77,983        0

c) The stockholders of the Company approved the non-binding, advisory proposal


    on the compensation of the Company's named executive officers. The results of
    the stockholders' vote with respect to the non-binding, advisory proposal
    were as follows:




                                    Broker
   For        Against    Abstain   Non-Votes
65,725,751   9,853,981   22,667    8,106,611

d) The stockholders of the Company approved an amendment to the Company's


    Restated Certificate of Incorporation to increase the number of authorized
    shares of the Company's Common Stock from 150,000,000 to 225,000,000. The
    amendment to the Company's Restated Certificate of Incorporation was filed
    with the Secretary of State of the State of Delaware on June 11, 2021. The
    results of the stockholders' vote with respect to the proposed amendment were
    as follows:




                                    Broker
   For        Against    Abstain   Non-Votes
82,016,485   1,639,406   53,119        0

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