Item 7.01 Regulation FD Disclosure

On September 22, 2021, Fifth Third Bancorp ("Fifth Third") published the required Basel III Pillar 3 Regulatory Capital Disclosures, which are available on Fifth Third's Investor Relations website at https://ir.53.com under "Quarterly and Annual Reports". These disclosures reference the Quarterly Report on Form 10-Q for the period ended June 30, 2021, the Annual Report on Form 10-K for the year ended December 31, 2020 and the Consolidated Financial Statements for Holding Companies - FR-Y-9C for the period ended June 30, 2021, which are also available on Fifth Third's Investor Relations website at https://ir.53.com under "Quarterly and Annual Reports". These disclosures will be published quarterly and will be available on Fifth Third's Investor Relations website. Fifth Third intends to discontinue filing a Form 8-K to announce publication for these reports for future periods.

The information in this Form 8-K shall not be deemed filed for purposes of Section 18 of the Securities Act of 1934, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, except as shall be expressly set forth by specific reference.

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