Q1 2021 Commercial Metrics

April 13, 2021

Commercial Metrics Overview

Preliminary ZILRETTA® net sales of $24.6 million in Q1 2021

4,417 accounts had purchased ZILRETTA, as of March 31, 2021; up from 4,248, as of December 31, 2020

  • 3,470 accounts had re-ordered ZILRETTA (79% of accounts that had purchased), as of March 31, 2021; up from 3,321 accounts that had re-ordered ZILRETTA (78% of accounts that had purchased) as of December 31, 2020
  • As of March 31, 2021, Flexion had ~$154 million in cash, cash equivalents and marketable securities and ~49.9 million shares outstanding

2

ZILRETTA Net Sales

Quarterly Since Launch

ZILRETTA Net Sales ($ Millions)

30

$26.3

25

$23.7

$23.7

$24.6

$21.8

20

$20.1

$17.0

$15.5

15

$10.6

10

$9.5

$7.0

5

$3.8

$2.2

$0.4

-

Q4 2017

Q1 2018

Q2 2018

Q3 2018

Q4 2018

Q1 2019

Q2 2019

Q3 2019

Q4 2019

Q1 2020

Q2 2020

Q3 2020

Q4 2020

Q1 2021

Note: Flexion recognizes ZILRETTA sales upon receipt of product by specialty distributors and pharmacies.

3

# of Accounts

Distribution of Accounts by ZILRETTA Purchases

Cumulative

5,000

4,500

4,248

4,417

4,072

3,858

4,000

3,672

3,488

1,358

3,500

3,130

3,000

2,733

2,500

2,247

1,186

2,000

1,837

1,500

1,434

1,000

953

530

1,873

500

115

0

Q4 2017

Q1 2018

Q2 2018

Q3 2018

Q4 2018

Q1 2019

Q2 2019

Q3 2019

Q4 2019

Q1 2020

Q2 2020

Q3 2020

Q4 2020

Q1 2021

Accounts purchased 1-10 units

Accounts purchased 11-50 units

Accounts purchased 51+ units

Flexion primarily sells ZILRETTA to specialty distributors and a specialty pharmacy; accounts (physicians, clinics, and certain medical centers or hospitals) subsequently

purchase ZILRETTA directly from these specialty distributors and the specialty pharmacy.

4

ZILRETTA Units

Distribution of ZILRETTA Purchases by Accounts

Cumulative

398,786

400,000

350,000

345,697

300,000

295,641

250,000

249,024

212,327

360,209

200,000

175,784

150,000

138,284

100,000

89,656

59,750

50,000

23,057

39,886

4,077

10,935

459

31,170

7,407

0

Q4 2017

Q1 2018

Q2 2018

Q3 2018

Q4 2018

Q1 2019

Q2 2019

Q3 2019

Q4 2019

Q1 2020

Q2 2020

Q3 2020

Q4 2020

Q1 2021

Accounts purchased 1-10 units

Accounts purchased 11-50 units

Accounts purchased 51+ units

Flexion primarily sells ZILRETTA to specialty distributors and a specialty pharmacy; accounts (physicians, clinics, and certain medical centers or hospitals) subsequently

purchase ZILRETTA directly from these specialty distributors and the specialty pharmacy.

5

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Disclaimer

Flexion Therapeutics Inc. published this content on 13 April 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 13 April 2021 20:08:06 UTC.