Flexion Therapeutics : Q4 2020 Commercial Metrics Overview

Q4 2020 Commercial Metrics

January 13, 2021

Overview

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Preliminary ZILRETTA® net sales of ~$26.3 million in Q4 2020 Net sales for full-year 2020 estimated to be ~$85.5 million

4,248 accounts had purchased ZILRETTA as of December 31, 2020; up from 4,072 as of September 30, 2020

• 3,321 accounts had re-ordered ZILRETTA (78% of accounts that had purchased), as of December 31, 2020; up from 3,153 accounts that had re-ordered ZILRETTA (77% of accounts that had purchased) as of September 30, 2020
• As of December 31, 2020, Flexion had ~$175 million in cash, cash equivalents and marketable securities and ~49.4 million shares outstanding

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ZILRETTA Net Sales

Quarterly Since Launch

ZILRETTA Net Sales ($ Millions)

30

$26.3

25		$23.7	$23.7
	$21.8	$20.1
20
	$17.0	$15.5
15
$9.5	$10.6
10
$7.0

5
$3.8
	$2.2
	$0.4
-

Q4 2017

Q1 2018

Q2 2018

Q3 2018

Q4 2018

Q1 2019

Q2 2019

Q3 2019

Q4 2019

Q1 2020

Q2 2020

Q3 2020

Q4 2020

Note: Flexion recognizes ZILRETTA sales upon receipt of product by specialty distributors and pharmacies.

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Distribution of Accounts by ZILRETTA Purchases

Cumulative

# of Accounts

4,500

4,000

3,500

3,000

2,500

2,000

1,500

1,000

500

0

													3,858	4,072	4,248
											3,488	3,672
										3,130				1,242
							2,733
						2,247									1,170
					1,837
			1,434
		953													1,836
	530
115
Q4 2017	Q1 2018	Q2 2018		Q3 2018	Q4 2018	Q1 2019	Q2 2019	Q3 2019	Q4 2019	Q1 2020	Q2 2020	Q3 2020	Q4 2020
				Accounts purchased 1-10 units			Accounts purchased 11-50 units

Flexion primarily sells ZILRETTA to specialty distributors and a specialty pharmacy; accounts (physicians, clinics, and certain medical centers or hospitals) subsequently purchase ZILRETTA from these specialty distributors and the specialty pharmacy.

4

Distribution of ZILRETTA Purchases by Accounts

Cumulative

	400,000																		345,697
	350,000
	300,000																	295,641
Units
																249,024
ZILRETTA	250,000															212,327
	200,000												175,784				307,988
	150,000											138,284
	100,000									59,750	89,656
	50,000				10,935	23,057	39,886
	0	459		4,077													30,482
																		7,227
	Q4 2017	Q1 2018	Q2 2018	Q3 2018	Q4 2018	Q1 2019	Q2 2019	Q3 2019	Q4 2019	Q1 2020	Q2 2020	Q3 2020	Q4 2020
				Accounts purchased 1-10 units			Accounts purchased 11-50 units			Accounts purchased 51+ units

Flexion primarily sells ZILRETTA to specialty distributors and a specialty pharmacy; accounts (physicians, clinics, and certain medical centers or hospitals) subsequently purchase ZILRETTA from these specialty distributors and the specialty pharmacy.

5

ZILRETTA Purchases by New and Existing Accounts

Cumulative

ZILRETTA Units

400,000

350,000

300,000

250,000

200,000

150,000

100,000

50,000

0

												345,697
											295,641	15,455
										249,024
									212,327
								175,784
							138,284					330,242
						89,656
459	4,077	10,935	23,057	39,886	59,750
0
Q4 2017	Q1 2018	Q2 2018	Q3 2018	Q4 2018	Q1 2019	Q2 2019	Q3 2019	Q4 2019	Q1 2020	Q2 2020	Q3 2020	Q4 2020

Existing Accounts		New Accounts

Flexion primarily sells ZILRETTA to specialty distributors and a specialty pharmacy; accounts (physicians, clinics, and certain medical centers or hospitals) subsequently purchase ZILRETTA from these specialty distributors and the specialty pharmacy.

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