Innovating Antibodies, Improving Lives
Investor Presentation
December 2020
Forward Looking Statement
This presentation contains forward looking statements. The words "believe", "expect", "anticipate", "intend" and "plan" and similar expressions identify forward looking statements. All statements other than statements of historical facts included in this presentation, including, without limitation, those regarding our financial position, business strategy, plans and objectives of management for future operations (including development plans and objectives relating to our products), are forward looking statements. Such forward looking statements involve known and unknown risks, uncertainties and other factors which may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by such forward looking statements. Such forward looking statements are based on numerous assumptions regarding our present and future business strategies and the environment in which we will operate in the future. The important factors that could cause our actual results, performance or achievements to differ materially from those in the forward looking statements include, among others, risks associated with product discovery and development, uncertainties related to the outcome of clinical trials, slower than expected rates of patient recruitment, unforeseen safety issues resulting from the administration of our products in patients, uncertainties related to product manufacturing, the lack of market acceptance of our products, our inability to manage growth, the competitive environment in relation to our business area and markets, our inability to attract and retain suitably qualified personnel, the unenforceability or lack of protection of our patents and proprietary rights, our relationships with affiliated entities, changes and developments in technology which may render our products obsolete, and other factors. Further, certain forward looking statements are based upon assumptions of future events which may not prove to be accurate. The forward looking statements in this document speak only as at the date of this presentation. Genmab does not undertake any obligation to update or revise forward looking statements in this presentation nor to confirm such statements to reflect subsequent events or circumstances after the date made or in relation to actual results, unless required by law.
2
Our Core Purpose, Strategy & Vision Guide Our Work
The Genmab Difference
Innovation Powerhouse Transforming Cancer Treatment & Creating Value
4
Track Record & Growth
38 Cumulative INDs since 1999
22 Genmab created product candidates in Ongoing Clinical Trials
Multiple Genmab-created Products Approved
7 Years of Profitability & Expanding Top Line
Dual-listed in US & DK with 2019 US IPO
5
Solid Foundation Built on a Differentiated Pipeline
Potential 1st-in-Class/Best-in-Class
Our Own Clinical Pipeline
R&D Engine
(innovaTV
Technologies & Pre-Clinical
-
• DuoBody-CD40x4-1BB7
-
• HexaBody®-DR5/DR5
-
• DuoHexaBody®-CD376
-
• DuoBody-CD3x5T46
Japanese
Solid Financial Base
Approved Partnered Products
•DARZALEX® (daratumumab) / DARZALEX FASPRO™ (daratumumab and hyaluronidase-fihj)1
•Kesimpta® (ofatumumab)2 •TEPEZZA® (teprotumumab)3 •Arzerra® (ofatumumab)4
Programs Built on Genmab's Innovation
Partner-owned Programs in the Clinic
-
• 15 product candidates in clinical development w/ partners
-
• Incl. 7 DuoBody products with Janssen, 1 with Novo Nordisk
6
1In dev. by Janssen; 2 in dev. by Novartis; 3In dev. by Horizon; 4Commercialized by Novartis, no longer in active development. 550:50 w/ Seagen; 650:50 w/ AbbVie; 750:50 w/ BioNTech, GEN1046 & GEN1042 respectively; 8Genmab is developing HexaBody-CD38 in an exclusive worldwide license and option agreement with Janssen Biotech, Inc
DARZALEX® (daratumumab) & DARZALEX FASPRO™ (daratumumab and hyaluronidase-fihj): Redefining Treatment of Multiple Myeloma
First-in-class CD38 antibody in development to treat cancer
Collaboration with Janssen: Genmab entitled to tiered royalty of 12-20% of net sales
Approved in certain territories for various multiple myeloma (MM) indications1
DARZALEX FASPRO first and only SubQ CD38 mAb approved in U.S. for treatment of MM
2019 WW net sales by J&J: $2,998M
7
See local country prescribing information for approved indications
DARZALEX Approvals: US and EU
On Track for Approval Across All Lines of MM Treatment
Daratumumab
Proving to be the Critical Driver Across Different Combinations & Treatment Lines
Frontline
Relapsed/Refractory
Ongoing Phase 3: CEPHEUS (D-VRd, NDMM NTE), PERSEUS (D-VRd, NDMM TE)
3Data as per ASCO 2019; 4Data as per ASH 2019
9
Improved Survival for Patients with Multiple Myeloma
Overall Survival Analysis from ALCYONE Trial
Kaplan-Meier estimates of overall survival in intention-to-treat population. Mateos, MV et al, 'Overall survival with daratumumab, bortezomib, melphalan, and prednisone in newly diagnosed multiple myeloma (ALCYONE): a randomized, open-label, phase 3 trial,' The Lancet, published online December 9, 2019
Kesimpta® (ofatumumab)
Approved in Relapsing Multiple Sclerosis
Human CD20 Antibody - well validated target
Injection for SubQ use approved for RMS in the US
First B-cell therapy that can be self-administered by patients at home using Sensoready® autoinjector pen
Second Genmab-created product with blockbuster potential
Developed by Novartis: Regulatory submission also
made in EU
Genmab 10% royalty payment of net sales
Tisotumab Vedotin
Genmab's Most Advanced Asset with Potential in Solid Tumors
Fully human antibody-drug conjugate (ADC) targeting Tissue Factor (TF) in development to treat solid tumors
License and collaboration agreement with Seattle
Genetics 50:50
Very favorable topline results, Phase 2 recurrent or metastatic cervical cancer
Ongoing trials in cervical, ovarian cancer, other solid tumors
Expanding development, additional studies planned
Tisotumab Vedotin in Cervical Cancer Designed to Address a High Unmet Medical Need
Clinically meaningful and durable responses observed*
N=101
|
Confirmed ORR (95% CI),a %
|
24 (15.9−33.3)
|
CR, n (%)
PR, n (%)
|
7 (7)
17 (17)
|
SD, n (%)
PD, n (%)
Not evaluable, n (%)
|
49 (49)
24 (24)
4 (4)
|
RemaininginResponse
0
No. at risk
0
|
2
|
4
|
6
|
8
|
10
|
12
|
Time (months)
|
24
|
22
|
16
|
11
|
8
|
3
|
0
|
*Data from innovaTV 204 study, Coleman R, et al. Tisotumab Vedotin in Cpreviously Treated Recurrent or Metastatic Cervical Cancer: Results from the Phase 2 innovaTV 204 / GOG-3023/ ENGOT-cx6 Study, ESMO September 21, 2020. Data cutoff: February 06, 2020. Median13 duration of follow-up: 10.0 months. CI, confidence interval; CR, complete response; DOR, duration of response; IRC, independent review committee; NR, not reached; ORR, objective response rate; PD, disease progression; PR, partial response; SD, stable disease.
Epcoritamab (DuoBody-CD3xCD20)
Potential for Improved Efficacy & Safety in B Cell Malignancies
Potential best-in-class therapeutic
T cell-mediated killing of CD20-expressing cells
SubQ Ph 3 trial in DLBCL announced
50:50 co-development Genmab and AbbVie
*Dose escaltion data presented on EHA25 Virtual Congress 2020 poster, Data cut-off dates: safety, April 24 2020; efficacy, May 14 2020
Anti-tumor activity
-
• 86% ORR in FL ≥ 0.76mg
-
• 60% ORR, incl. 3 pts who failed prior CAR-T treatment, in DLBCL/HGBCL ≥12 mg
-
• Emerging prelim. data highly encouraging with substantial single-agent efficacy
-
• Induces rapid and deep responses in heavily pretreated pts with B-NHL across different subtypes
Safety
-
• No DLTs observed; MTD has not been reached
-
• No treatment-related deaths
-
• No discontinuation due to AEs unrelated to disease progression
-
• No Grade ≥ 3 CRS events observed
DuoHexaBody-CD37 (GEN3009)
Building Our Pipeline: First DuoHexaBody in the Clinic
Combination of DuoBody & HexaBody platforms
Novel target for hematologic malignancies
Unique mechanism-of-action
Dose escalation ongoing
50:50 co-development Genmab and AbbVie
DuoBody-CD3x5T4 (GEN1044)
Latest in the Clinic
Based on proprietary DuoBody technology
CD3 bispecific, T cell mediated cytotoxicity of 5T4+ tumor cells
5T4 expressed on multiple solid
tumors limited expression in healthy
tissue
Dose-escalation ongoing
50:50 co-development Genmab and AbbVie
DuoBody-PD-L1x4-1BB (GEN1046)
Bispecific Next Generation Checkpoint Immunotherapy
First-in-Class Bispecific antibody targeting PD-L1 & 4-1BB (CD137)
Designed to activate T cells through conditional
4-1BB co-stimulation, while simultaneously
blocking the PD1/PD-L1 axis
Combining T cell stimulation with
checkpoint blockade
Ph 1/2 study ongoing in solid tumors
50:50 co-development Genmab and BioNTech
DuoBody-CD40x4-1BB (GEN1042)
Bispecific Agonistic Antibody
Bispecific antibody targeting CD40 & 4-1BB (CD137)
Conditionally activates T cells and APC in presence of CD40-expressing cells
Phase 1/2 study ongoing in solid tumors
50:50 co-development Genmab and BioNTech
See local country prescribing information for approved indications
HexaBody-DR5/DR5 (GEN1029)
First HexaBody in Clinical Development
Targets 2 distinct DR5 epitopes
HexaBody platform - DR5 clustering & DR5 agonist activity
First 100% Genmab-owned HexaBody product in
clinic
Phase 1/2 study ongoing in multiple solid tumors
2020 Guidance: Recurring Revenue Growth and Focused Investments
Key Observations
Income Statement
|
DKKM
|
~USDM*
|
Revenue
Operating Expenses
Operating Income
|
9,250 - 9,850
(3,850) - (3,950)
5,350 - 5,950
|
1,423 - 1,515
(592) - (608)
823 - 915
|
*2020 Guidance - November 4, 2020 / USD 1.00 = DKK 6.50.
-
• DARZALEX royalties of ~DKK 4.1bn to ~DKK 4.5bn to drive recurring revenue growth
-
• Nearly 90% of USD 750M upfront from AbbVie collab. recognized immediately
-
• Growth in operating expenses driven by expanding and accelerating our clinical pipeline
DARZALEX Sales of USD 3.9bn - USD 4.2bn
-
• Significant opportunity for growth in 1L MM market
-
• SubQ DARZALEX approvals in H1 in U.S. & EU
-
• Market share gain in the U.S. and RoW driven by uptake in all lines of treatment
Key 2020 Priorities
Building a Strong Differentiated Product Pipeline
Priority
Genmab proprietary* products
** ***
-
» Tisotumab vedotin - data on other solid tumor types
-
» Enapotamab vedotin - data to support late stage development
Daratumumab4
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» Epcoritamab (DuoBody-CD3xCD20)2 Phase 1/2 - decision on recommended Phase 2 dose & initiate expansion cohorts
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» HexaBody-DR5/DR5 Phase 1/2 - advance dose escalation
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» DuoBody-PD-L1x4-1BB3 Phase 1/2 - initiate expansion cohorts
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» DuoBody-PD-L1x4-1BB initial data in H2 2020
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» File INDs and/or CTAs for 2 new products
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» U.S. FDA and EMA decision on Phase 3 COLUMBA multiple myeloma SubQ submission
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» sBLA and MAA Submission Phase 3 ANDROMEDA amyloidosis
-
» sBLA and MAA submission Phase 3 APOLLO multiple myeloma
Ofatumumab5
*Certain product candidates in development with partners, as noted. **Data anticipated in 2021 ***Development will not advance 1. 50:50 dev. w/ Seagen; 2. 50:50 dev w/ AbbVie; 3. 50:50 dev. w/ BioNTech; 4. In dev. by Janssen; 5. In dev. by Novartis; 6. In dev. by Horizon Therapeutics
Delivering on Genmab's Promise: Innovating Antibodies, Improving Lives
Pipeline of 1st-in-class / best-in-class therapies advancing through clinic
Unique R&D engine & strategic alliances
Developing new capabilities to bring own product to market
Creating Substantial
Value
World-class team with track record of successSignificant earnings potential from marketed products
Innovating Antibodies, Improving Lives
Appendix
A Leading International Biotech With Large Free Float
As of September 30, 2020
Genmab & AbbVie: Collaboration Overview
A broad, long-termoncology collaboration with Genmab and AbbVie working together to jointly make all strategy, clinical development and commercialization decisions
*Source: Company information and filings.
50/50 partnership across three clinical next-generation bispecific antibody product candidates (epcoritamab, DuoHexaBody-CD37, DuoBody-CD3x5T4)
Genmab to book epcoritamab sales in the U.S. and Japan; AbbVie to commercialize epcoritamab RoW - Genmab to receive tiered royalties on RoW net sales
Fourth* largest oncology partnership with total potential value ~USD 3.9bn (up-front cash + milestone payments) to Genmab
Advancing Pipeline: Delivering on Our Promise & Creating Value Accelerating Development of Potential "Next Winners"
DuoBody-CD3xCD20 (epcoritamab)
-
• Potential best-in-class: SubQ administration
-
• Pre-clinical / preliminary clinical data shows encouraging safety & efficacy
-
• Expeditious and comprehensive clinical development plan
-
• RP2D decision & expansion cohorts initiation
-
• 50:50 AbbVie
DuoBody-PD-L1x4-1BB (GEN1046)
Promise for Patients
Advancing Pipeline: Delivering on Our Promise & Creating Value
•DuoBody-CD40x4-1BB1; DuoHexaBody-CD372; DuoBody-CD3x5T42; HexaBody-CD383
Bolstering early stage portfolio
Delivering on Genmab's Promise to Patients
Expanding early stage discovery programs
1GEN1042, 50:50 w/ BioNTech; 250:50 w/ AbbVie; 3Genmab is developing HexaBody-CD38 in an exclusive worldwide license and option agreement w/ Janssen Biotech, Inc
Enhancing clinical development capabilities
Genmab's Commitment to Society
Building a Socially Responsible & Sustainable Company
Anchored in our Core Purpose & Vision
CSR Committee comprised of representatives from variety of functions, chaired by
Focus on four main areas
CEO
Innovation Powerhouse:
Cutting Edge Proprietary Technologies
Technology
Principle
Applications
DuoBodyBispecific antibodies
Dual targeting
Target-mediated enhanced hexamerizationEnhanced potency
DuoHexaBodymediated enhanced hexamerization
Bispecific antibodies with target-Dual targeting + enhanced potency
HexElectwith target-mediated enhanced hexamerization
Two co-dependent antibodiesDual targeting + enhanced potency & selectivity
Innovative Clinical and Pre-Clinical Pipeline Genmab's Proprietary1 Products
Product
TargetDeveloped By Disease IndicationsMost Advanced Development Phase
Pre-Clinical
1
1/2
Tisotumab vedotin
TF
50:50 Genmab Cervical cancer / Seattle
GeneticsEpcoritamab (DuoBody-CD3xCD20)CD3, CD20 50:50 Genmab / AbbVie
DuoBody-PD-L1x4-1BB (GEN1046)
PD-L1, 4-1BB
50:50 Genmab / BioNTech
HexaBody-DR5/DR5 (GEN1029)
DR5
Genmab
DuoBody-CD40x4-1BB (GEN1042)
CD40, 4-1BB
50:50 Genmab / BioNTech
DuoHexaBody-CD37 (GEN3009)
CD37
50:50 Genmab / AbbVie
DuoBody-CD3x5T4 (GEN1044)
CD3, 5T4
50:50 Genmab / AbbVie
IND/CTAs in 2020
HexaBody-CD38 (GEN3014)2
GenmabOvarian cancer
Solid tumors
Hematological malignancies
Solid tumors
Solid tumors
Solid tumors
Hematologic malignancies
Solid tumors
1Certain product candidates in development with partners, as noted. 2Genmab is developing HexaBody-CD38 in an exclusive worldwide license and option agreement with Janssen Biotech, Inc
2
3
Approved
Products Created by Genmab*
Including Proposed Label Expansions for Marketed Products
Product
TargetDeveloped ByDisease Indications
Most Advanced Development Phase
Pre-ClinicalDARZALEX (daratumumab) & DARZALEX FASPRO (daratumumab and hyaluronidase-fihj)
DaratumumabCD38
Janssen (Tiered royalties to Genmab on net global sales)Kesimpta (ofatumumab)CD20
Novartis (Royalties to Genmab on net global sales)Arzerra (ofatumumab)CD20
Novartis
TEPEZZA (teprotumumab-trbw)TeprotumumabIGF-1R
Horizon Therapeutics (under sublicense from Roche, royalties to Genmab on net global sales)
*Out-licensed products marketed by partner 1See local country prescribing information for precise indications, 2Not in active development
1
1/2
2
3
Approved
Partner-owned Products Incorporating Genmab's Innovation*
Product
TargetDeveloped By
Disease Indications
Pre-Clinical
Amivantamab (JNJ-61186372)
EGFR, cMetJanssen
Teclistamab
(JNJ-64007957)
BCMA, CD3
Janssen
PRV-015
(AMG 714)
IL-15
Provention Bio
Camidanlumab tesirine
(ADCT-301)
CD25
ADC Therapeutics
Mim8
FIX(a), FXNovo Nordisk
Talquetamab
(JNJ-64407564)
GPRC5D, CD3
Janssen
JNJ-63709178
CD123, CD3
Janssen
JNJ-63898081
PSMA, CD3
Janssen
JNJ-67571244
CD33, CD3
Janssen
JNJ-70218902
UndisclosedJanssen
HuMax-IL8
Lu AF82422
IL8 alpha-Synuclein
BMS
LundbeckNon-small-cell lung cancer (NSCLC)
Relapsed /Refractory Hodgkin Lymphoma
Solid tumors
Healthy volunteers & hemophilia A
Relapsed or refractory MM
Acute Myeloid Leukemia (AML)
Solid tumors
Relapsed or refractory AML or MDS
Solid tumors
Advanced cancers
Parkinson's disease
*Out-licensed Products under development by a third-party incorporating Genmab technology and innovation
Most Advanced Development Phase
1
1/2
2
3
Approved
Solid Foundation Built on a Differentiated Pipeline Tisotumab Vedotin Clinical Program
Recurrent or metastatic cervical cancer
-
• Single arm, monotherapy
-
• 1° endpoint: confirmed ORR
-
• 2° endpoints: duration of response, PFS, OS
-
• In combo or mono
-
• 1° endpoint: ORR
-
• 2° endpoints: Safety, duration of response, time to response, PFS, OS
-
• Basket study
-
• 2° endpoints: Safety, disease control rate, duration of response, time to response, PFS, OS
-
• Ovarian cancer, fallopian tube cancer, peritoneal cancer
-
• 2 schedules: q3wk & dose dense
-
• 1° endpoints: Safety & ORR
Tisotumab Vedotin Cervical Cancer Market Size
In developed countries, incidence rates are low (<7.9 per 100,000 women) compared with developing countries in sub-Saharan Africa and Central and South America, where incidence is especially high (>30 per 100,000 women)5
*Europe is defined as the 40 countries in the four United Nations-defined areas of Europe and the European Union (EU-27).
References: 1. American Cancer Society 2. .EUCAN (2012) 3. Centers for Disease Control and Prevention. Cervical Cancer Statistics (2017) 4. UpToDate.
5. Ginsburg O et al. Lancet 2017 6. HPV Information Centre Japan (2017)
HexaBody-CD38 (GEN3014)
Expanding the Potential of CD38 Antibodies
Covering All Stages of MM and Beyond: Key Ongoing* Industry Sponsored Trials
Disease
Therapy
Development Phase
Pre-Clinical
High Risk Smoldering MMFront line MM (transplant & non-transplant)
Relapsed or Refractory MMALL
Subcutaneous
Monotherapy
Dara + VRd
Dara + VMP (Asia Pacific)
Dara + VRd
Dara + R (maintenance)
Dara + combinations
Dara + I.O. (PD1 & PDL1)
Dara + SoC chemo
V = Velcade® , MP = melphalan-prednisone , T = thalidomide d = dexamethasone, R = Revlilmid®, K = Kyprolis®, Pom = Pomalyst®
*Does not include trials that may still be ongoing but have clinical data and/ or are the basis for an existing approval.
1
1/2
2
3
Daratumumab Efficacy in Newly Diagnosed Multiple Myeloma Updated Phase 3 MAIA Trial (D+Rd, NTE): ASH Dec 2019
D = daratumumab; R = lenalidomide; d = dexamethasone; PFS = progression free survival; MRD - minimal residual disease
-
• Median PFS not reached in D-Rd arm
-
• MRD-negativity significantly higher with D-Rd vs. Rd (29% vs 9%; P<0.0001)
-
• No new safety concerns
-
• Results continue to support use of D-Rd in 1st line treatment of TIE pts with NDMM
Janssen Sponsored Phase 3 & 4
Daratumumab Trials Sponsored by Pharma / Biotech
Ct.gov Identifier
|
Phase
|
Sponsor
|
Indication
|
Therapy
|
NCT03768960
|
4
|
J&J Private Ltd
|
Relapsed or Refractory MM
|
Daratumumab (MMY4008)
|
NCT02252172
|
3
|
Janssen
|
Untreated MM
|
Daratumumab + Rd (MAIA)
|
NCT02195479
|
3
|
Janssen
|
Untreated MM
|
Daratumumab + VMP (ALCYONE)
|
NCT02541383
|
3
|
Janssen
|
Untreated MM
|
Daratumumab + VTd (CASSIOPEIA)
|
NCT02076009
|
3
|
Janssen
|
Relapsed or Refractory MM
|
Daratumumab + Rd (POLLUX)
|
NCT02136134
|
3
|
Janssen
|
Relapsed or Refractory MM
|
Daratumumab + Vd (CASTOR)
|
NCT03180736
|
3
|
Janssen
|
Relapsed or Refractory MM
|
Daratumumab + Pom-d (APOLLO)
|
NCT03201965
|
3
|
Janssen
|
Amyloidosis
|
Daratumumab + CyBorD (ANDROMEDA)
|
NCT03217812
|
3
|
Janssen
|
Untreated MM
|
Daratumumab + VMP (Asia Pacific) (OCTANS)
|
NCT03234972
|
3
|
Janssen
|
Relapsed or Refractory MM
|
Daratumumab + Vd vs Vd (LEPUS)
|
NCT03277105
|
3
|
Janssen
|
Relapsed or Refractory MM
|
Daratumumab SubQ vs IV (COLUMBA)
|
NCT03301220
|
3
|
Janssen
|
Smoldering MM
|
Daratumumab SubQ (AQUILA)
|
NCT03652064
|
3
|
Janssen
|
Untreated MM
|
Daratumumab + VRd (CEPHEUS)
|
NCT03710603
|
3
|
Janssen/EMN
|
Untreated MM
|
Daratumumab + VRd (PERSEUS)
|
NCT03901963
|
3
|
Janssen
|
Untreated MM / Maintenance
|
Daratumumab + R (AURIGA)
|
Janssen Sponsored Phase 1 & 2
Daratumumab Trials Sponsored by Pharma / Biotech
Ct.gov Identifier
NCT03384654
NCT02951819
NCT02874742
NCT02316106
NCT02927925
NCT03412565
NCT03871829
NCT03011034
NCT01615029
NCT02852837
NCT02519452
NCT02918331
NCT03242889
NCT01998971
NCT04108195
NCT04121260
Phase
Sponsor Janssen Janssen Janssen Janssen Janssen Janssen Janssen Janssen Janssen Janssen Janssen Janssen Janssen
Indication
2
2
2
Relapsed / Refractory ALL / LL Untreated and Relapsed MM Untreated MM
2
2
Smoldering MM NKTCL, Nasal Type
2
2
Newly diag. & relapsed / refractory MM Dara retreatment
2
MDS
1/2
1
1
1
Relapsed and Refractory MM Relapsed or Refractory MM Relapsed or Refractory MM Untreated MM
1
Relapsed or Refractory MM
1
Janssen
Various MM
1
1
Janssen Janssen
Multiple Myeloma Multiple Myeloma
Therapy
Dara + Vincristine + Prednisone + Doxorubicin (DELPHINUS) Daratumumab + CyBorD (LYRA)
Daratumumab + VRd (GRIFFIN) Monotherapy (CENTAURUS) Monotherapy (VOLANS)
Daratumumab SubQ + Rd, VMP & VRd (PLEIADES) Daratumumab SubQ+ Kd vs Kd (LYNX) Daratumumab (or talacotuzumab) (MDS2002) Daratumumab + Rd (GEN503)
Monotherapy (in China) (MMY1003) Monotherapy, subcutaneous (PAVO) Daratumumab + Rd (Japan) (MMY1006) Daratumumab subq (Japan) (MMY1008)
Daratumumab + backbone regimens (Vd, VMP, VTd, Pom-d, Kd, KRd) (EQUULEUS)
Daratumuamb + either talquetamab or teclistamab (MMY1002) Subcutaneous monotherapy (in China) (MMY1010)
Other Industry Sponsored Trials
Daratumumab Trials Sponsored by Pharma / Biotech
Ct.gov IdentifierPhase
NCT03158688 3
NCT01946477 2
NCT02807454 2
NCT03439293 2
NCT03314181 2
NCT02807558 2
NCT02773030 1/2
NCT02343042 1/2
NCT03481556 1/2
NCT01592370 1/2
NCT03837509 1/2
NCT03989414 1/2
NCT02431208 1
Sponsor
Amgen Celgene Celgene Takeda AbbVie
Syros Pharma Celgene Karyopharm
Oncopeptides AB
Indication
Relapsed or Refractory MM Relapsed or Refractory MM Relapsed and Refractory MM Relapsed or Refractory MM Relapsed or Refractory MM AML or MDS
Relapsed or Refractory MM Relapsed or Refractory MM
Relapsed or Refractory MM
BMS Incyte Celgene Roche
Relapsed or Refractory MM Relapsed or Refractory MM Various MM
Resistant or Refractory MM
Therapy
Daratumumab + Kd (CANDOR) Daratumumab + Pom-d Daratumumab + Imfinzi (FUSION) Daratumumab + NINLARO (ixazomib) + Dex Daratumumab + Venetoclax + Dex (w/ or w/out bortezomib) Daratumumab + SY-1425
Daratumumab + CC-220 + Dex Daratumumab + Selinexor + Dex (STOMP)
Daratumumab + Melflufen + Dex (ANCHOR)
Daratumumab + nivolumab
Daratumumab + INCB001158 Daratumumab + CC-92480 Daratumumab + Tecentriq (atezolizumab)
NCT03068351 1
Roche
Resistant or Refractory MM
Daratumumab + RO6870810
NCT04045028 1
NCT04136756 1
Genentech Nektar Thera.
Relapsed or Refractory MM Salvage for MM
Daratumumab + tiragolumab Daratumumab + NKTR-255
www.genmab.com