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    GSK   GB0009252882

GLAXOSMITHKLINE PLC

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CureVac-GSK coronavirus variant vaccine generates good immune response in rats

05/17/2021 | 03:59am EDT
FILE PHOTO: Dose of CureVac vaccine or a placebo is seen in Brussels

LONDON (Reuters) - A second-generation COVID-19 vaccine developed by CureVac and GlaxoSmithKline, designed to protect against coronavirus variants, produced a high level of immune response in a trial in rats, the companies said on Thursday.

CureVac in February said it would team up with GlaxoSmithKline on a COVID-19 vaccine aimed at targeting several variants with one shot.

The shot uses messenger RNA technology, similar to successful vaccines made by Pfizer-BioNTech and Moderna, and clinical trials of the shot in humans are expected to start in the third quarter of this year.

The mRNA "backbone" of the shot differs from CureVac's first COVID-19 vaccine candidate, and it is designed to work well at lower doses.

Rats immunised with the shot, called CV2CoV, showed quick, strong immune responses, the companies said, and blood serum "showed significant cross-neutralization against variants first discovered in Denmark (B.1.1.298), the UK (B.1.1.7) and South Africa (B.1.351)."

"To successfully fight the COVID-19 pandemic in the long term, we will need different vaccines and we need to be able to respond effectively to emerging variants," GSK Global Vaccines President Roger Connor said.

"We are pleased with these pre-clinical results as they show the potential of the next generation mRNA technology we are developing together with CureVac."

Although human trials are yet to start, these results mark a boost for GSK, the world's largest vaccine maker by sales.

GSK's collaboration with CureVac is a fresh attempt to play a major role in fighting the pandemic after a COVID-19 shot with Sanofi ran into delays and a collaboration with China's Clover Biopharmaceuticals was ended.

GSK, which acquired a 10% stake in CureVac last year, will also support the production of up to 100 million doses of CureVac's first-generation COVID-19 vaccine candidate.

CureVac's first generation COVID-19 vaccine is already in late-stage clinical trials.

(Reporting by Alistair Smout; Editing by Susan Fenton)

By Alistair Smout


© Reuters 2021
Stocks mentioned in the article
ChangeLast1st jan.
BIONTECH SE -0.75% 227.79 Delayed Quote.181.53%
CUREVAC N.V. 5.01% 59.76 Delayed Quote.-29.80%
DOW JONES AFRICA TITANS 50 INDEX 0.43% 530.1 Delayed Quote.-0.26%
DOW JONES SOUTH AFRICA(ZAR) 0.00% 1895.08 Delayed Quote.6.93%
GLAXOSMITHKLINE PLC -0.24% 1405.8 Delayed Quote.5.14%
MODERNA, INC. 3.82% 220.14 Delayed Quote.102.97%
PFIZER, INC. 0.36% 39.19 Delayed Quote.6.09%
S&P AFRICA 40 INDEX 0.00% 171.18 Delayed Quote.-1.34%
SANOFI 0.55% 87.6 Real-time Quote.11.31%
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Financials
Sales 2021 33 138 M 46 171 M 46 171 M
Net income 2021 3 770 M 5 253 M 5 253 M
Net Debt 2021 21 587 M 30 077 M 30 077 M
P/E ratio 2021 19,1x
Yield 2021 5,67%
Capitalization 70 605 M 98 153 M 98 375 M
EV / Sales 2021 2,78x
EV / Sales 2022 2,61x
Nbr of Employees 94 066
Free-Float 92,3%
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Number of Analysts 27
Last Close Price 1 411,00 GBX
Average target price 1 518,30 GBX
Spread / Average Target 7,60%
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Managers and Directors
NameTitle
Emma N. Walmsley Chief Executive Officer & Executive Director
Iain James Mackay Chief Financial Officer & Executive Director
Jonathan Richard Symonds Non-Executive Chairman
Karenann K. Terrell Chief Digital & Technology Officer
Hal V. Barron Executive Director & Chief Scientific Officer
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