Item 1.02 Termination of a Material Definitive Agreement.

On February 5, 2020, GlycoMimetics, Inc. (the "Company") received written notice from Pfizer Inc. ("Pfizer") of Pfizer's termination of the License Agreement by and between the Company and Pfizer, dated October 7, 2011, as amended (the "License Agreement"), effective April 5, 2020.

Upon termination, all rights and licenses granted to Pfizer under the License Agreement will terminate and Pfizer will return to the Company the rights to develop and commercialize the products subject to the License Agreement, including rivipansel, and will grant the Company a non-exclusive license to use the intellectual property developed by Pfizer in connection with its development of such products, subject to the terms of the License Agreement. The Company will work with Pfizer to effectuate any necessary transition activities regarding the subject matter of the License Agreement, and will be determining what, if any, next steps to take with respect to the rivipansel program after reviewing the Phase 3 data more completely.

The Company will not incur any termination penalties as a result of the termination of the License Agreement.

A summary of the material terms and conditions of the License Agreement is set forth in the Company's Annual Report on Form 10-K filed with the Securities and Exchange Commission (the "Commission") on March 6, 2019. The License Agreement is filed as Exhibit 10.1 to Amendment No. 2 to the Registrant's Registration Statement on Form S-1 (File No. 333-191567), filed with the Commission on October 31, 2013. The description of the terms and conditions of the License Agreement contained in this Current Report on Form 8-K and the summary contained in the Annual Report on Form 10-K referenced above do not purport to be complete and are qualified in their entirety by reference to the full text of the License Agreement.













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