Great Panther Announces Mineral Resource Estimates for the Topia Mine and Guanajuato Mine Complex in Mexico

VANCOUVER - Great Panther Mining Limited (TSX: GPR) (NYSE-A: GPL) ('Great Panther' or the 'Company'), a growth-oriented precious metals producer focused on the Americas, reports Mineral Resource Estimates for the Company's 100%-owned Topia Mine and Guanajuato Mine Complex ('GMC') in Mexico.

The estimates were prepared in accordance with National Instrument 43-101 - Standards of Disclosure for Mineral Projects ('NI 43-101').

The Company will file a technical report in respect of each of Topia and GMC, prepared in each case in accordance with NI 43-101, on SEDAR and EDGAR within 45 days of this news release.

Topia Highlights

Measured and Indicated ('M&I') Mineral Resource grade increased 8% to 1,041 silver equivalent grams per ton ('Ag eq g/t'), when compared with the 2018 MRE for Topia.

M&I Mineral Resources decreased 25% to 11.1 million silver equivalent ounces ('Ag eq oz'), when compared with the 2018 MRE.

GMC Highlights

M&I Mineral Resource grade increased 2% to 391 grams Ag eq g/t when compared with the 2020 MRE for GMC.

M&I Mineral Resources decreased 36% to 7.7 million Ag eq oz when compared with the 2020 MRE.

Topia Mineral Resource Estimate Update

Topia lies northwest of Durango and is a silver ('Ag'), gold ('Au'), lead ('Pb'), zinc ('Zn') district with a central concentrator plant capable of processing 260 tonnes per day ('tpd'), supporting multiple mine headings on precious and base metal veins. Topia has been in the Great Panther portfolio since 2005 and has cumulatively produced 9.5 million silver equivalent ounces (comprised of silver and gold) plus 17,574 tonnes of lead and 23,592 tonnes of zinc.

The MRE for Topia has an effective date of March 31, 2021. Compared to the previous MRE with an effective date of July 31, 2018, grades have significantly increased with M&I grades increasing 32% for silver, 37% for gold, 14% for lead and 11% for zinc. The higher-grade ore, however, is associated with an overall decrease of 30% in tonnes and 25% in silver equivalent ounces. Key factors that varied during the three-year period since the last MRE were the increase in mining costs, metal price variations and mine depletion, which totalled 3.7 million Ag eq oz.

In contrast to the 2018 MRE, current resource estimations include the addition of block models for veins in the San Juan, Union de Pueblo and Hipolito areas. Geological re-interpretation added veins at 1522 and Recompensa mines.

Guanajuato Mine Complex Mineral Resource Estimate Update

GMC is comprised of the Guanajuato and San Ignacio silver and gold underground mines and the 1,000 tpd Cata processing plant, located in the prolific Guanajuato mining district. GMC has been in the Great Panther portfolio since 2005 and has cumulatively produced 30 million silver equivalent ounces. In the fourth quarter of 2021, the Guanajuato mine and Cata processing plant were placed on care and maintenance and mining operations were suspended at the San Ignacio mine while the Company continues to await the permits necessary to extend the tailings dam or finds other alternatives to maximize value from the GMC.

The MRE for the GMC has an effective date of July 31, 2021 . GMC contains estimated M&I Mineral Resources of 519,493 tonnes above varying USD Net Smelter Return ('USD NSR') cut-off values equivalent to full operational cost, at an average grade of 196 g/t Ag and 2.30 g/t Au, for a total of 6,537,755 Ag eq oz or 76,915 Au eq oz. This includes Measured Mineral Resources of 368,944 tonnes at an average grade of 196 g/t Ag and 2.36 g/t Au, for a total of 4,708,345 Ag eq oz or 55,392 Au eq oz and Indicated Mineral Resources of 150,550 tonnes at an average grade of 194 g/t Ag and 2.16 g/t Au, for a total of 1,829,410 Ag eq oz or 21,522 Au eq oz. In addition, estimated Inferred Mineral Resources are 665,977 tonnes at an average grade of 194 g/t Ag and 2.42 g/t Au, for 8,558,540 Ag eq oz or 100,689 Au eq oz.

Compared to the previous MRE with an effective date of July 31, 2020, silver and gold grades remained largely constant. For the M&I Mineral Resource, the average silver grade decreased 1% while gold increased 11%. The most significant change in the M&I Mineral Resource is the mass with the tonnes decreasing by 47%. Two key factors influenced this: better definition of historical workings and areas with operational restrictions and limitation of M&I to areas within 20 metres of positive channel sampling within underground development. Underground development led to the removal of some resource blocks due to a better definition of historical mine workings or through the demonstration of less favourable mine conditions, for example mineralization discontinuities or poor ground conditions. In parallel, the geology team has embarked on a major project of developing a 3D exploration model for each of the deposits, which will help identify the controls on mineralization zones to guide focused exploration.

Cautionary Note Regarding Absence of Mineral Reserve Estimates

There are no current estimates of Mineral Reserves for any of the GMC or Topia mines. The Company made decisions to enter production at GMC and Topia without having completed final feasibility studies. EUR EUR Accordingly, the Company did not base its production decisions on any feasibility studies of Mineral Reserves demonstrating economic and technical viability of the GMC and Topia mines. EUR EUR As a result, there may be increased uncertainty and risks of achieving any particular level of recovery of minerals or the costs of such recovery. EUR EUR As GMC and Topia do not have established Mineral Reserves, the Company faces higher risks that anticipated rates of production and production costs will not be achieved. These risks could have a material adverse impact on the Company's ability to continue to generate anticipated revenues and cash flows to fund operations from and ultimately achieve or maintain profitable operations at GMC or Topia associated with its production plan.

ABOUT GREAT PANTHER

Great Panther is a growth-oriented precious metals producer focused on the Americas. The Company owns a diversified portfolio of assets in Brazil, Mexico and Peru that includes three gold and silver mines, an advanced development project, and a large land package with district-scale potential. Great Panther is focused on creating long-term stakeholder value through safe and sustainable production, reinvesting into exploration and pursuing acquisition opportunities to complement its existing portfolio. Great Panther trades on the Toronto Stock Exchange trading under the symbol GPR, and on the NYSE American under the symbol GPL.

CAUTIONARY STATEMENT ON FORWARD-LOOKING INFORMATION

This news release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995 and forward-looking information within the meaning of Canadian securities laws (together, 'forward-looking statements'). Such forward-looking statements may include, but are not limited to, statements regarding (i) the Company's ability to execute its growth plan and to unlock value from its asset portfolio, (ii) the Mineral Resource estimates and the assumptions underlying the estimates (iii) the Company's ability to secure a permit to extend the tailings storage facility for the GMC mine or to successfully find other alternatives to maximize the value of GMC, and (iv) the potential of 3D modelling creating adequate targets for further exploration.

These forward-looking statements and information reflect the Company's current views with respect to future events and are necessarily based upon a number of assumptions that, while considered reasonable by the Company, are inherently subject to significant operational, business, economic and regulatory uncertainties and contingencies. These assumptions include: continued operations and exploration work in 2022 occur without significant interruption due to COVID-19 or any other reason; the accuracy of the Company's resource estimate at Topia and GMC and the assumptions upon which they are based, ore grades and recoveries; prices for gold, silver, and base metals remaining as estimated; currency exchange rates remaining as estimated; prices for energy inputs, labour, materials, supplies and services (including transportation); all necessary permits, licenses and regulatory approvals for the Company's operations and exploration work are received in a timely manner on favourable terms the ability to procure equipment and operating supplies without interruption and that there are no material unanticipated variations in the cost of energy or supplies; operations not being disrupted by issues such as pit-wall failures or instability, mechanical failures, labour disturbances and workforce shortages, illegal occupations or mining, seismic events, and adverse weather conditions and the Company's ability to comply with environmental, health and safety laws. The foregoing list of assumptions is not exhaustive.

These forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results, performance or achievements expressed or implied by such forward-looking statements to be materially different. Such factors include, among others, risks and uncertainties relating to: the impact of COVID-19 on the Company's ability to operate and conduct exploration work, including drilling plans, as anticipated, and the risk of an unplanned partial or full shutdown of the Company's mines and processing plants, whether voluntary or imposed, which would adversely impact the Company's revenues, financial condition and ability to meet its production and cost guidance and fund its capital programs and repay its indebtedness; the inherent risk that estimates of Mineral Reserves and Resources may not be accurate and accordingly that mine production will not be as estimated or predicted; planned exploration activities, may not result in the discovery of new Mineral Resources/definition of Mineral Resources and readers are cautioned that Mineral Resources that are not Mineral Reserves have no defined economic viability; gold, silver and base metal prices may decline or may be less than forecasted; fluctuations in currency exchange rates may increase costs of operations; operational and physical risks inherent in mining operations (including pit wall collapses, tailings storage facility failures, environmental accidents and hazards, industrial accidents, equipment breakdown, unusual or unexpected geological or structural formations, cave-ins, flooding and severe weather) may result in unforeseen costs, shut downs, delays in production and drilling and exposure to liability; potential political and social risks involving Great Panther's operations in a foreign jurisdiction; the potential for unexpected costs and expenses or overruns; shortages in the ability to procure equipment and operating supplies without interruption; employee and contractor relations; relationships with, and claims by, local communities; the Company's ability to obtain all necessary permits, licenses and regulatory approvals in a timely manner on favourable terms; changes in laws, regulations and government practices in the jurisdictions in which the Company operates; legal restrictions related to mining; diminishing quantities or grades of mineral reserves as properties are mined operating or technical difficulties in mineral exploration, changes in project parameters as plans continue to be refined; the Company's inability to meet its production forecasts or to generate the anticipated cash flows from operations could result in the Company's inability to meet its scheduled debt payments when due or to meet financial covenants to which the Company is subject or to fund its exploration programs as planned; ability to maintain and renew agreements with local communities to support continued operations; there is no assurance that the Company will be able to identify or complete acquisition opportunities of, if completed, that such acquisitions will be accretive to the Company; the risk that incremental closure bond requirements with respect to the Company's Coricancha mine could have a material and adverse effect on the company's liquidity and could require additional financing to be raised; the Company's ability to raise additional financing as debt comes due and other risks and uncertainties, including those described in respect of Great Panther in its most recent annual information form, and management's discussion and analysis and material change reports filed with the Canadian Securities Administrators available at www.sedar.com and reports on Form 40-F and Form 6-K filed with the Securities and Exchange Commission and available at www.sec.gov.

There is no assurance that these forward-looking statements will prove accurate or that actual results will not vary materially from these forward-looking statements. Although the Company has attempted to identify important factors that could cause actual results to differ materially, there may be other factors that cause results not to be as anticipated, estimated, described, or intended. Accordingly, readers are cautioned not to place undue reliance on forward looking statements. Forward-looking statements and information are designed to help readers understand management's current views of our near- and longer-term prospects and may not be appropriate for other purposes. The Company does not intend, nor does it assume any obligation to update or revise forward-looking statements or information, whether as a result of new information, changes in assumptions, future events or otherwise, except to the extent required by applicable law.

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