Guard Therapeutics International AB (publ) announced positive top line results from the final and highest dosage group as part of a clinical phase 1a study where single ascending doses (SAD) of the investigational drug ROSgardTM were administered to healthy subjects. ROSgard also demonstrated good pharmacokinetic properties and a favourable safety profile at this dosage level, which is higher than the one that is expected to be used in future patient studies. The next stage in the phase 1a programme is to study ROSgard in multiple ascending doses (MAD). With what is called the SAD part of the clinical phase 1a study now successfully concluded, Guard Therapeutics will apply to commence dosage of ROSgard in multiple ascending doses (MAD) in healthy subjects, based on an existing conditional approval from the Swedish Medical Products Agency. The company is anticipating that it will be possible to conclude the remaining part of the phase 1a programme during summer 2020. In parallel with this, a separate phase 1 study is underway to document the investigational drug's pharmacokinetics in individuals with reduced kidney function who have not started dialysis treatment.