Item 1.01. Entry into a Material Definitive Agreement.

On January 1, 2021, Guardant Health, Inc. (the "Company") entered into an Amendment #5 to Supply Agreement (the "Amendment") with Illumina, Inc. ("Illumina"), which amends that certain Supply Agreement, dated September 15, 2014, by and between the Company and Illumina, as amended (the "Supply Agreement"), pursuant to which Illumina provides the Company products and services used for certain research and clinical activities, including certain sequencers, equipment and other materials the Company uses in its laboratory operations. The Amendment provides for, among other things, extending the term of the Supply Agreement to January 2033. The term of the Supply Agreement will automatically renew for successive one-year periods after January 2033 unless the Supply Agreement is terminated earlier in accordance with its terms or either party provides notice of non-renewal to the other party of not less than 12 months prior to the date such renewal would otherwise take effect. Under the terms of the Amendment, the Company may also terminate the Supply Agreement for convenience upon 90 days' prior written notice. The Amendment also updated the list of specific hardware and consumables, including associated pricing terms for each, to be provided by Illumina to the Company.

The foregoing description of the Amendment does not purport to be complete and is qualified in its entirety by reference to the full text of the Amendment, a copy of which will be filed as an exhibit to the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2020.

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