On August 5, 2021, Guardant Health, Inc. announced that its board of directors approved a co-chief executive officer (Co-CEO) leadership structure for the company and that effective on August 5, 2021, the company appointed AmirAli Talasaz as the company’s Co-CEO and changed the title of Helmy Eltoukhy, the company’s current Chief Executive Officer, to the company’s Co-CEO. Dr. Talasaz has also announced his intent to resign from his position as chief operating officer of the company, effective as of the Effective Date, but he will continue to serve as president of the company. Dr. Eltoukhy will lead the company’s oncology division while Dr. Talasaz will oversee the company’s screening division. As Co-CEOs, the compensation of Drs. Eltoukhy and Talasaz will remain unchanged.