Quarterly Report 2022

June

At a Glance

Profile and Portfolio

HBM Healthcare Investments invests in the human medicine, biotechnology, medical technology and diagnostics sectors and related areas. The company holds and actively manages an international portfolio of promising companies.

Many of these companies have their lead products already available on the market or at an advanced stage of development. The portfolio companies are closely tracked and actively guided on their strategic directions. This is what makes HBM Healthcare Investments an interesting alternative to investing in big pharma and biotech companies. HBM Health- care Investments has an international shareholder base and is listed on SIX Swiss Exchange (ticker: HBMN).

HBM Healthcare Investments Ltd / Quarterly Report June 2022

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Currency allocation of assets 1)

Emphasis on US dollar investments.

62% US dollar (USD) 2)

20% Renminbi (CNY)

9% Euro (EUR)

4% Other currencies

(CAD, DKK, GBP, HKD, SEK)

3% Indian rupee (INR)

2% Swiss franc (CHF) 2)

Allocation of assets 1)

Mainly invested in private companies or in companies originating from the private companies portfolio.

38%

Public (from private)

companies

16%

Public companies

29%

Private companies

8%

Funds

7%

Cash and cash equivalents

2%

Other assets

Development phase of portfolio companies 3)

Mainly invested in revenue generating companies or in ­companies with products at an advanced stage of ­development.

Investments by continents 3)

Global portfolio.

Western Europe 15%

North and South America 51%

Asia 34%

45%

Profitable

24%

Products on the market

5%

Phase III

14%

Phase II

5%

Phase I

7%

Preclinical

Therapeutic area of the lead product of portfolio companies 3)

Broadly diversified areas of activity.

22%

Synthetic Biology

20%

Others

18%

Central Nervous System

16%

Oncology

7%

Digital Health

7%

Immunology / Inflammation

5%

Orphan diseases

4%

Medical technology / 

  1. Total consolidated assets as at 30.6.2022: CHF 2 230 million.
  2. Net of foreign currency hedge (USD/CHF): about USD 54 percent and CHF 10 percent respectively.
  3. Total investments as at 30.6.2022: CHF 2 021 million.

diagnostics

1% Infectious diseases

At a Glance

HBM Healthcare Investments Ltd / Quarterly Report June 2022

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Key Figures and Performance

Key Figures

30.6.2022

Net assets

CHF million

2 038.0

Investments in private companies and funds

820.2

Investments in public companies

1 200.7

Cash and cash equivalents

(net of liability from market hedging)

166.7

Net result for the period

CHF million

51.6

Basic earnings per share

CHF

7.41

Net asset value (NAV) per share

CHF

292.94

Share price

CHF

265.00

Premium (+) / discount (-)

%

- 9.5

Distribution per share

CHF

Distribution yield

%

Shares issued

Registered shares (m)

7.0

Shares outstanding

Registered shares (m)

7.0

31.3.2022

31.3.2021

31.3.2020

31.3.2019

1 986.5

2 151.5

1 448.8

1 318.3

790.3

662.8

706.4

542.1

1 130.2

1 404.2

629.9

688.2

223.7

327.0

224.2

176.2

- 78.0

756.3

182.7

209.1

- 11.22

108.71

26.26

30.05

285.53

309.25

208.25

189.48

276.00

332.50

190.00

168.80

- 3.3

+7.5

- 8.8

- 10.9

9.70

12.50 1)

7.70

7.50

3.5

3.8

4.1

4.4

7.0

7.0

7.0

7.0

7.0

7.0

7.0

7.0

  1. Thereof CHF 9.50 as ordinary distribution and CHF 3.00 as a special distribution to mark the 20th anniversary of the Company.

Performance (including distributions)

2022/2023

(3 months)

2021/2022

2020/2021

2019/2020

2018/2019

Net asset value (NAV)

%

2.6

- 3.6

52.2

13.9

18.1

Registered share HBMN

%

- 4.0

- 13.2

79.1

17.0

22.1

Indexed performance since launch in CHF (12.7.2001 = 100), dividends reinvested

560

500

HBM Healthcare Investments Share

440

380

320

NASDAQ Biotechnology Index

HBM Healthcare Investments NAV

260

200

140

MSCI World Health Care Index

80

20

1.7.2012

30.6.2013

30.6.2014

30.6.2015

30.6.2016

30.6.2017

30.6.2018

30.6.2019

30.6.2020

30.6.2021

30.6.2022

Management Report

HBM Healthcare Investments Ltd / Quarterly Report June 2022

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1 April to 30 June 2022

HBM Healthcare Investments achieved a net profit of CHF 52 million in the first quarter of the 2022/2023 financial year in an overall declining market environment. The net asset value per share rose by 2.6 percent, while the share price fell by 4 percent. The positive quarterly result is largely owed to three acquisitions from the portfolio of public companies. With an operationally successful portfolio and a high level of cash and cash equivalents, HBM Healthcare Investments is well positioned in an environment that continues to be characterised by volatility and uncertainty. The Company hedged one fifth of the US dollar Swiss franc currency risk.

Dear Shareholders

HBM Healthcare Investments closed the first quarter of the 2022/2023 financial year as at 30 June 2022 with a net profit of CHF 52 million. The net asset value per share (NAV) increased by 2.6 percent, while the share price declined by 4 percent. Overall, the equity markets in the healthcare sector recorded declining valuations (MSCI World Health Care Index - 3.9 percent, Nasdaq Biotechnology Index - 6.6 percent, SPDR S&P Biotech - 14.6 percent).

Three acquisitions of portfolio companies led to quarterly profit

Three acquisitions from the portfolio of public companies dominated the reporting quarter and contributed a total of CHF 70 million to quarterly profits. All companies were acquired at significant premiums of between 40 and 120 percent over the prices traded on the stock exchange.

  • In mid-April, GlaxoSmithKline announced the acquisition of Sierra Oncology for USD 1.9 billion. HBM Healthcare Investments began building a small stake in Sierra in February 2021 and increased this investment to around CHF 17 million in the first quarter of 2022 following the publication of phase III trial results for momelotinib for the treatment of myelofibrosis patients. In total, the investment resulted in a gain of CHF 21 million. CHF 16 million of this is attributable to the current financial year.

Management Report

HBM Healthcare Investments Ltd / Quarterly Report June 2022

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1 April to 30 June 2022

  • In May, Pfizer announced the acquisition of Biohaven Pharmaceuticals for USD 11.6 billion. This followed a strategic partnership between the two companies at the end of 2021 for the marketing of Biohaven's migraine drug Nurtec® ODT by Pfizer outside the United States. In the wake of this partnership, Biohaven acquired all the shares not already held in its subsidiary Bioshin, which is developing Nurtec® ODT for the Chinese market. HBM Healthcare invested around CHF 34 million in Biohaven since 2019 and also took a CHF 7 million stake in Bioshin in 2020. The acquisitions of Biohaven and Bioshin resulted in a profit of around CHF 63 million for HBM Healthcare Investments. Thereof, CHF 14 million was generated in the quarter just ended.
  • Lastly, at the beginning of June, Bristol-Myers Squibb signed an agreement to acquire Turning Point Therapeutics for USD 4.1 billion. HBM Healthcare Investments has held a stake in Turning Point since 2018, still a private company at the time, and invested around CHF 15 million before and at the time of the IPO. The position was actively managed after flotation. Overall, HBM Healthcare Investments generated a profit of CHF 65 million from the investment, of which CHF 40 million was generated in the current financial year.

The other assets were CHF 10 million lower in value overall.

High level of cash and cash equivalents

As of the balance sheet date at the end of June 2022, the company reported cash and cash equivalents of CHF 167 million. This does not include the proceeds of approximately CHF 125 million from the acquisitions of Turning Point Therapeutics and Biohaven Pharmaceuticals, which are expected to close in the third quarter of 2022 and early 2023, respectively.

No new investments were made in private companies during the quarter under review. CHF 18 million went to existing private companies as follow-on financing. Mineralys Therapeutics accounted for just under half of this. The company closed a USD 118 million financing round at a higher company valuation. The funds will be used for further clinical development of MLS-101, a novel treatment approach for patients with hypertension.

In the public companies' segment, new positions were selectively added to the portfolio and existing holdings were increased.

Overall, the composition of the portfolio changed little compared to the previous quarter. Due to the strong rise of the US dollar against the Swiss franc, about one fifth of the US dollar currency risk was hedged.

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Disclaimer

HBM Healthcare Investments AG published this content on 18 July 2022 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 22 July 2022 07:13:04 UTC.