Item 5.02 Departure of Directors or Certain Officers; Election of Directors;

Appointment of Certain Officers; Compensatory Arrangements of Certain

Officers.

(e) The Compensation Committee of our Board of Directors previously approved the amendment and restatement of our Amended and Restated 2020 Equity Incentive Plan (the "2020 Plan"), subject to shareholder approval, to, among other things, increase the aggregate number of our ordinary shares authorized for issuance under the 2020 Plan by 4,800,000 shares (the "Amended 2020 Plan"). On April 28, 2022, our shareholders approved the Amended 2020 Plan.

A complete copy of the Amended 2020 Plan is filed herewith as Exhibit 99.1. The above summary of the Amended 2020 Plan does not purport to be complete and is qualified in its entirety by reference to such exhibit.

Item 5.07 Submission of Matters to a Vote of Security Holders.

Set forth below are the results of the matters submitted for a vote of shareholders at our 2022 Annual General Meeting of Shareholders held on April 28, 2022.

Proposal 1 - Election of directors.

The following directors were elected to serve for three-year terms until the 2025 Annual General Meeting of Shareholders and until their respective successors are duly elected and qualified.



Director Elected           For            Against        Abstain       Broker Non-Votes
Michael Grey            133,104,780       55,303,847       58,239              7,998,580
Jeff Himawan, Ph.D.     183,759,968        4,633,555       73,343              7,998,580
Susan Mahony, Ph.D.     184,749,569        3,646,326       70,971              7,998,580

Proposal 2 - Approval of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2022 and the authorization of the Audit Committee of our Board of Directors to determine the auditors' remuneration.

For Against Abstain Broker Non-Votes 193,700,761 2,717,730 46,955

           0


Proposal 3 - Approval, on an advisory basis, of the compensation of our named executive officers.

For Against Abstain Broker Non-Votes 170,922,400 16,051,800 1,492,666 7,998,580

Proposal 4 - Authorization for us and/or any of our subsidiaries to make market purchases or overseas market purchases of our ordinary shares.

For Against Abstain Broker Non-Votes 188,194,146 240,687 32,033 7,998,580

Proposal 5 - Approval of our Amended 2020 Plan.

For Against Abstain Broker Non-Votes 173,858,804 14,539,750 68,312 7,998,580

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

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Exhibit No.                                  Description

99.1                Horizon Therapeutics Public Limited Company Amended and
                  Restated 2020 Equity Incentive Plan, 2020 Restricted Stock Unit
                  Award Sub-Plan and Form of Option Agreement, Form of Stock Option
                  Grant Notice, Forms of Restricted Stock Unit Agreement and Forms
                  of Restricted Stock Unit Grant Notice thereunder.

104               Cover Page Interactive Data File (embedded within the Inline XBRL
                  document).

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