Hua Medicine announced the completion of patient enrollment for a Phase III monotherapy trial of HMS5552 (dorzagliatin). The Phase III monotherapy registration trial targets drug naïve T2D patients, positioning dorzagliatin as first-line therapy. The monotherapy trial is a double-blind, placebo-controlled study and patients are randomized 2:1 to receive either dorzagliatin or placebo. The clinical study evaluates the efficacy and safety of dorzagliatin with 24 weeks of double-blinded treatment plus 28-week open-label treatment, and follow-up. The trial is being conducted in 40 clinical sites across China. Dorzagliatin is a first-in-class glucokinase activator, or GKA, designed to control the progressive degenerative nature of diabetes by restoring glucose homeostasis in Type 2 diabetics. Hua Medicine in-licensed the global rights to dorzagliatin from Roche. By addressing the defect of the glucose sensor function of glucokinase, or GK, dorzagliatin has the potential to repair the impaired glucose homeostasis state of Type 2 diabetics and serve as a first-line standard of care therapy for the treatment of Type 2 diabetes, or as a cornerstone therapy when taken in combination with currently approved anti-diabetes drugs.