- Initiated a Phase 1 trial of Icosavax’s first combination bivalent vaccine candidate, IVX-A12, against respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) in older adults -
- IVX-A12 is the first bivalent vaccine candidate against both RSV and hMPV to reach clinical stage development -
- Cash and cash equivalents, restricted cash, and short-term investments of
“The past few months have marked a pivotal moment for
Third Quarter 2022 and Subsequent Highlights
- Initiated Phase 1 trial of IVX-A12 against RSV and hMPV in older adults. In October, the company announced the initiation of a Phase 1 clinical trial of IVX-A12, a combination bivalent RSV and hMPV VLP vaccine candidate, in older adults. IVX-A12 is comprised of IVX-121, Icosavax’s RSV prefusion F protein VLP vaccine candidate, and IVX-241, Icosavax’s hMPV prefusion F protein VLP vaccine candidate. IVX-A12 is the first candidate from Icosavax’s novel VLP platform to receive IND authorization in the
U.S. Icosavax anticipates announcing topline results from this Phase 1 trial in mid-2023, and subsequently plans to initiate a Phase 2 trial for IVX-A12 in 2H 2023.
Near-Term Milestone Expectations
- IVX-121 (RSV) Phase 1b extension, 6-month immunogenicity data expected by early 2023
- IVX-121 (RSV) Phase 1b extension, 12-month immunogenicity data expected in mid-2023
- IVX-A12 (RSV+hMPV) Phase 1 topline interim data expected in mid-2023
- IVX-A12 (RSV+hMPV) Phase 2a initiation expected in 2H 2023
- COVID-19 bivalent candidate selection expected in 2023
- Flu program candidate selection expected in 2023
Third Quarter Financial Results
- Cash, cash equivalents, restricted cash, and short-term investments as of
September 30, 2022 were$222.5 million , compared to$280.7 million as ofDecember 31, 2021 .Icosavax currently expects its cash balance to be sufficient to fund operations through at least 2024. - Research and development (R&D) expenses for the three months ended
September 30, 2022 , were$15.5 million compared to$10.9 million for the same period in 2021. The increase was primarily driven by increased clinical development activity, and increased personnel related expenses and stock-based compensation expense. Research and development expenses include non-cash stock-based compensation expenses of$2.0 million for the three months endedSeptember 30, 2022 . - General and administrative (G&A) expenses for the three months ended
September 30, 2022 were$7.7 million , compared to$25.4 million for the same period in 2021. The decrease was primarily from lower stock-based compensation expense, due to$21.0 million in one-time, non-cash stock-based compensation expense from the acceleration of options in connection with the death of the company’s former co-founder and Chairman (Tachi Yamada ) in 2021, offset by increased personnel costs, increased professional services and insurance costs, and other operating expenses to support the Company’s growth. General and administrative expenses include non-cash stock-based compensation expenses of$3.4 million for the three months endedSeptember 30, 2022 . - Net loss for the three months ended
September 30, 2022 was$22.0 million , or a basic and diluted net loss per share of$0.55 . This includes non-cash stock-based compensation expense of$5.4 million . Net loss for the same period in 2021 was$34.4 million , or a basic and diluted net loss per share of$1.30 .
About
For more information, visit www.icosavax.com.
Forward-Looking Statements
Statements contained in this press release regarding matters that are not historical facts are forward-looking statements. The forward-looking statements are based on the company’s current beliefs and expectations and include, but are not limited to: the company’s expectation regarding the opportunities for, and the prophylactic and commercial potential of, its vaccine candidates and technology platform; the company’s ability to advance its development program and achieve the noted development milestones in 2022 and 2023; and the sufficiency of the company’s current cash, cash equivalents, and investments to fund its operations through at least 2024. Actual results may differ from those set forth in this press release due to the risks and uncertainties inherent in the company’s business, including, without limitation: the early stage of the company’s development efforts; the company’s approach to the development of vaccine candidates, including its plan to develop a combination bivalent RSV/hMPV VLP vaccine candidate, which is a novel and unproven approach; potential delays in the development process including without limitation in candidate development, IND submission, the commencement, enrollment, conduct of, and receipt of data from, clinical trials; unexpected adverse side effects or inadequate immunogenicity or efficacy of the company’s vaccine candidates that may limit their development, regulatory approval, and/or commercialization; results from preclinical studies or early clinical trials not necessarily being predictive of future results; the company’s dependence on third parties in connection with manufacturing, research, and clinical testing; the potential for challenges encountered in the manufacturing and scale up process, including without limitation challenges that reduce drug product stability or potency; competing approaches limiting the commercial value of the company’s vaccine candidates; regulatory developments in
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Condensed Balance Sheets
(Unaudited)
(in thousands)
2022 | 2021 | |||||||
Assets | ||||||||
Current assets: | ||||||||
Cash and cash equivalents | $ | 64,505 | $ | 279,082 | ||||
Restricted cash | 1,061 | 1,642 | ||||||
Short-term investments | 156,894 | — | ||||||
Prepaid expenses and other current assets | 6,272 | 5,829 | ||||||
Total current assets | 228,732 | 286,553 | ||||||
Right-of-use assets – operating leases | 3,330 | — | ||||||
Property and equipment, net | 11,815 | 1,076 | ||||||
Total assets | $ | 243,877 | $ | 287,629 | ||||
Liabilities and stockholders' equity | ||||||||
Current liabilities: | ||||||||
Accounts payable | $ | 4,722 | $ | 3,899 | ||||
Accrued and other current liabilities | 6,720 | 4,757 | ||||||
Current portion of operating lease liabilities | 1,591 | — | ||||||
Deferred revenue | — | 582 | ||||||
Total current liabilities | 13,033 | 9,238 | ||||||
Operating lease liabilities, net of current portion | 5,089 | — | ||||||
Other noncurrent liabilities | 93 | 171 | ||||||
Total liabilities | 18,215 | 9,409 | ||||||
Stockholders' equity: | ||||||||
Common stock | 5 | 5 | ||||||
Additional paid-in capital | 388,480 | 372,284 | ||||||
Accumulated other comprehensive loss | (609) | — | ||||||
Accumulated deficit | (162,214) | (94,069) | ||||||
Total stockholders' equity | 225,662 | 278,220 | ||||||
Total liabilities and stockholders' equity | $ | 243,877 | $ | 287,629 |
Condensed Statements of Operations and Comprehensive Loss
(Unaudited)
(in thousands, except share and per share data)
Three Months Ended | Nine Months Ended | |||||||||||||||
2022 | 2021 | 2022 | 2021 | |||||||||||||
Grant revenue | $ | — | $ | 1,827 | $ | 582 | $ | 5,732 | ||||||||
Operating expenses: | ||||||||||||||||
Research and development | 15,484 | 10,883 | 49,217 | 24,713 | ||||||||||||
General and administrative | 7,659 | 25,357 | 21,292 | 28,669 | ||||||||||||
Total operating expenses | 23,143 | 36,240 | 70,509 | 53,382 | ||||||||||||
Loss from operations | (23,143) | (34,413) | (69,927) | (47,650) | ||||||||||||
Other income (expense): | ||||||||||||||||
Change in fair value of embedded derivative liability | — | — | — | (205) | ||||||||||||
Loss on extinguishment of convertible promissory note | — | — | — | (754) | ||||||||||||
Interest and other | 1,167 | 27 | 1,782 | (180) | ||||||||||||
Total other income (expense) | 1,167 | 27 | 1,782 | (1,139) | ||||||||||||
Net loss | $ | (21,976) | $ | (34,386) | $ | (68,145) | $ | (48,789) | ||||||||
Comprehensive loss: | ||||||||||||||||
Unrealized losses on available-for-sale debt securities | (334) | — | (609) | — | ||||||||||||
Comprehensive loss | $ | (22,310) | $ | (34,386) | $ | (68,754) | $ | (48,789) | ||||||||
Net loss per share, basic and diluted | $ | (0.55) | $ | (1.30) | $ | (1.72) | $ | (4.50) | ||||||||
Weighted-average common shares outstanding, basic and diluted | 39,748,984 | 26,494,914 | 39,623,357 | 10,836,894 |
Source:
2022 GlobeNewswire, Inc., source