Immunicum AB (publ) will present positive data from its ADVANCE II Phase II study at the 63rdAmerican Society of Hematology (ASH) Annual Meeting being held in Atlanta, Georgia from December 11-14, 2021. The Phase II data demonstrate the ability of DCP-001 to convert or significantly reduce detectable minimal residual disease (MRD) in acute myeloid leukemia (AML) patients, with fully converted patients demonstrating greater overall survival. The results of the trial also reinforced data from a preceding Phase I trial demonstrating intradermal injection of DCP-001 to be generally well-tolerated. The Phase II study enrolled twenty-six AML patients in complete remission (CR) following chemotherapy induction, but who remained MRD positive and were therefore deemed to be at elevated risk of relapse. Of twenty patients with evaluable MRD levels post-vaccination, six demonstrated a measurable improvement in MRD status with four of those patients converting from MRD positive to MRD negative, and two patients achieving a substantial reduction in MRD throughout the course of the trial. Patients who converted from MRD positive to MRD negative over the course of the trial were observed to have improved survival over those not having fully converted. An additional seven patients remained in CR with stable MRD levels and only six patients encountered relapse. Intradermal injections of DCP-001 were well tolerated, with only limited drug related side effects. No serious adverse events were reported in conjunction with DCP-001. Patients in the ADVANCE II trial were divided into two cohorts, with each administered a different dose level of DCP-001 biweekly for four times, followed by additional booster administrations at weeks 14 and 18. MRD responses were recorded at 14, 20, and 32 weeks and patients were followed for up to 70 weeks after first administration. Median follow up of patients was 389 and 224 days for the two dose cohorts respectively. The primary endpoint of the study is MRD response, and the projected secondary endpoints of relapse free survival (RFS) and overall survival (OS) are still to be evaluated. The trial is continuing follow-up on patients to assess MRD responses over time and to assess relapse free (RFS) and overall (OS) survival.