Innovent Biologics, Inc. announced that the results of the Phase Ib clinical trial of IBI302, a first-in-class ophthalmic recombinant human anti-VEGF and anti-complement bi-specific fusion protein for neovascular age-related macular degeneration (nAMD) is released in e-poster at 2021 American Academy of Ophthalmology. The Phase Ib study of IBI302 is a randomized, open-label, positive-controlled, multi-center, repeated-dose clinical trial to evaluate the safety and tolerability of multi-intravitreal injection of IBI302 in patients with nAMD. A total of 18 subjects were enrolled in the completed Phase Ib clinical trial. All subjects received multi-intravitreal injection of IBI302 or Eylea?. Treatment with IBI302 was safe and well tolerated, with no report of dose limiting toxicity, treatment related adverse events nor treatment related serious adverse events. Visual acuity improvement and reduction in retinal edema were observed in subjects at 4 weeks after three loading treatments: in the 12 subjects in the IBI302 group, best-corrected visual acuity improved by a mean of 6.4 letters from baseline and mean central zone retinal thickness decreased by 129.3 ?m from baseline. In the 4 mg IBI302 group, visual acuity improved by 8.0 letters and mean central zone retinal thickness improved by 134.3 ?m. IBI302 is an innovative drug independently developed by Innovent for the treatment of fundus diseases. It is globally the first anti-VEGF/anti-complement bispecific molecule and has been supported by the major new drug project of the Ministry of Science and Technology as a Class 1 new drug. IBI302 was designed to be a more targeted treatment and interventions to AMD by including one additional target, thus providing more clinical benefits compared to anti-VEGF antibody. The results presented by the current Phase Ib clinical trial have brought greater confidence in the next phase of IBI302 research and development.