International Biotechnology Trust : Factsheet

December 2021 Factsheet

Why Biotech Investment

Investing in biotech is a way to support a highly innovative sector that is addressing high unmet medical needs. The pace of innovation is increasing, as is demand for biotech's products, and this leads to a dynamic, growth sector that offers investors the potential opportunity for good returns while simultaneously creating a positive social impact.

Investment Objective & Policy

The investment objective of International Biotechnology Trust plc (the "Company") is to seek to achieve long-term capital growth by investing primarily in biotech and other life sciences companies that are either quoted or unquoted and possess the potential for high growth. The Company invests in companies whose shares are considered to have good prospects, with experienced management and strong potential upside through the development and/or commercialisation of a product, device or enabling technology.

Driven by strong fundamentals of the biotech sector.

Access to a broad spectrum of quoted and unquoted investments in the biotech sector.

Provides investors exposure to both potential growth and a competitive yield.

Stocks selected on merit with consideration given to portfolio diversification.

Scientifically and financially experienced Fund Managers with access to specialists at SV Health.

Invested in companies at the cutting edge of biotech innovation.

Performance

5 year performance %

Source: Bloomberg, mid-price (share price), quoted in sterling and SV Health Managers LLP.

Past performance is not a guide to future performance. Note: All performance data are quoted net of all costs to the Company.

Discrete Performance	YTD	2020	2019	2018	2017	2016
NAV per share						-0.6%
-4.2%	29.8%	19.9%	-4.9%	8.2%
Share price						1.6%
-5.7%	36.1%	14.4%	-2.5%	18.3%
NBI						6.1%
-0.2%	23.2%	21.1%	-3.3%	11.1%
FTSE All-Share Index						16.8%
16.7%	-9.0%	19.7%	-9.5%	13.1%

Source: Bloomberg, mid-price (share price), quoted in sterling and SV Health Managers LLP. Past performance is not a guide to future performance. YTD and 1 year performance is from 30/12/2020 to 31/12/2021.

Fund Facts and Characteristics

Launch date	6 May 1994
Net assets	£306.2m
Net assets per share	743.8p
Share price	748p
Value of unquoted investments	£27.3m
(Gearing)/ cash balance	-18%
Number of portfolio companies	81*
Shares outstanding	41,168,847
Ex-div date	December 2021

Dividend policy 4% of NAV p.a. bi-annually

Ongoing costs, including 0.9% management fee, are 1.2% of the company's NAV

Performance Fee: See page 31 of the Annual

Report 2021

Continuation Vote: At AGM in 2023; every two years

Year / Interim End: 31 August / 28 February

*Excludes 21 companies held by SV Fund VI

Total Return

Total Return	1 M	1 YR	3 YR	5 YR
NAV per share				53.3%
3.7%	-4.2%	49.1%
Share Price				69.3%
4.4%	-5.7%	46.9%
NBI				60.0%
-3.2%	-0.2%	49.0%
FTSE All-Share Index				30.1%
4.7%	16.7%	27.2%

Source: Bloomberg, mid-price (share price), quoted in sterling and SV Health Managers LLP. Past performance is not a guide to future performance. YTD and 1 year performance is from 30/12/2020 to 31/12/2021.

Return vs Volatility

5 Years Annualised Chart (%)

Source: Bloomberg, mid-price (share price), quoted in sterling and SV Health Managers LLP. Past performance is not a guide to future performance. YTD and 1 year performance is from 30/12/2020 to 31/12/2021.

Share Codes

Listing	London Stock Exchange
Reuters / Bloomberg	IBT.L / IBT LN
Sedol	0455934 GB1
ISIN	GB0004559349

Investment Manager Review

In December 2021, the Trust's NAV per share returned 3.7% (GBP) while the NASDAQ Biotechnology Index (NBI) returned -3.2% (GBP). The FTSE All-Share Index returned 4.7% (GBP) and the S&P 500 Index returned 4.5% (GBP). IBT's share price returned 4.4% (GBP).

Source: Bloomberg and SV Health Managers LLP. Past performance is not a guide to future performance. Unless where stated otherwise, performance is shown net of fees and expenses and includes reinvestment dividend and capital gain distributions.

Quoted Portfolio

The main positive contributors to the NAV in the month were Amgen, Biohaven and Vertex. Amgen received FDA approval for their drug tezepelumab (Tezspire) for the treatment of asthma. Biohaven shares recovered from a previous decline caused by news of a collaboration with Pfizer for their migraine drug Nurtec in November which reduced the likelihood of it being an acquisition target. Vertex announced positive clinical data from a phase 2 trial in focal segmental glomerulosclerosis (FSGS), a rare kidney condition.

The main detractors from the NAV in the month were Alnylam, BridgeBio and Uniqure. BridgeBio announced disappointing phase 3 data for their drug acoramidis which is in development to investigate the treatment of a rare progressive heart condition called transthyretin mediated cardiomyopathy. Alnylam shares fell as they near the outcome of a similar trial that now carries a higher risk of failure. Uniqure reported early, but the limited data led to disappointment for those hoping for more conclusive results for their gene- therapy treatment for Huntington's disease

Unquoted Portfolio

The Trust's investment in venture capital fund, SV Fund VI, has generated a GBP net IRR of 23.0% since the date of the Trust's first investment. The Trust received a distribution from SV Fund VI during December, amounting to £0.9m. The distribution is being made in connection with the receipt of funds related to Bioventus, Inc. Deciphera Pharmaceuticals, Inc. Pionyr Immunotherapeutics, Inc. and Aligned Telehealth, Inc. As SV Fund VI is in the harvesting stage of its life, in accordance with the Trusts strategy to maintain its exposure to unquoted companies within a 5%-15% of NAV range, the Board of International Biotechnology Trust plc has made the decision to invest in SV Health Investors' forthcoming biotechnology focussed private fund, SV Biotech Crossover Opportunities Fund LP.

Contact Us

AIFM and Investment Manager	Company Secretary
SV Health Managers LLP	Company Matters, Link Group
71 Kingsway, London WC2B 6ST	Auditor
Lucy Costa Duarte	PricewaterhouseCoopers LLP
T: [phone]	Broker
E: [e-mail]
W: www.ibtplc.com	Numis Securities Ltd

Management Team

Ailsa Craig

Lead Investment Manager

Ailsa joined SV Health in 2006 and was appointed as

Joint Lead Fund Manager of the Trust in March 2021.

Ailsa has a BSc (Hons) in Biology from the University of

Manchester. She was awarded the IMC in 2002 and the

Securities Institute Diploma in 2007.

Marek Poszepczynski

Lead Investment Manager

Marek joined SV Health in 2014 and was appointed as Joint Lead Fund Manager of the Trust in March 2021. Marek has an MSc in Biochemistry and an MSc in Business Management from the Royal Institute of Technology, Stockholm.

Kate Bingham

Managing Partner SV

Kate joined SV Health in 1991 and represents the team of investment professionals managing the unquoted portfolio. Kate is a Managing Partner at SV Health Investors, has a first class degree in Biochemistry from Oxford University, and graduated from Harvard Business School with an MBA.

Houman Ashrafian

Managing Partner SV

Houman joined SV in 2016 and represents the team of investment professionals managing the unquoted portfolio. Houman is currently Head of Experimental Therapeutics at the University of Oxford and an Honorary Consultant Cardiologist, John Radcliffe Hospital, Oxford.

2

Portfolio Exposure

As at 31 December 2021

Top quoted investments by NAV%

Amgen											7.8%
Neurocrine										5.7%
Alnylam									5.2%
Incyte								5.1%
Gilead							5.0%
Biohaven						4.7%
Mirati					4.5%
PTC				4.3%
Seagen			4.2%
Vertex		4.1%
Total	50.6%

NAV% by	NAV% by Size
Development		Mega Cap > USD 30BN
Stage		Large Cap = USD 10 - 30BN
	Profitable		Mid cap = USD 2 - 10BN
		Small cap < USD 2BN
	Revenue Growth		SV Fund VI
	Early stage		Directly-held unquoted
All values quoted in %	All values quoted in %

NAV % by Headquarter Location	NAV% by Therapeutic Area
	Rare diseases							31%
	Oncology								33%
	CNS							15%
	Auto-immune						6%
	Infectious diseases					4%
	Ophthalmology				2%
	SV Fund VI			5%
	Other			4%

95%US / Canada 3% EU/UK 2% Rest of World

3

Discount/Premium

Control Mechanism

The Board regularly reviews the methods for managing both the discount and premium. The Board considers that conducting share buybacks can help to manage the discount of its share price to NAV, therefore enhancing share price performance for existing Shareholders. When the share price is trading at a premium to NAV, Shareholders have given the Board permission to reissue shares previously bought back or new shares at a premium to NAV.

AIFM and Investment Manager

SV Health Managers LLP was appointed Investment Manager of the Company on 1 January 2005 and Alternative Investment Fund Managers ('AIFM') on 21 July 2014.

Between November 2000 and December 2004, Schroder Ventures Life Sciences Advisers (UK) Ltd, was adviser to the Investment Manager of the Company during that period, Schroder Investment Management Ltd.

SV Health Managers LLP's venture capital business advises six venture capital funds with capital commitments of over USD 2bn which primarily invest amounts of between USD 1m and USD 20m in North America and Europe, but will consider innovative investments in other regions.

SV Health Managers LLP manages the SV7 Impact Medicine Fund, a specialist USD 265m venture capital biotech fund and the Dementia Discovery Fund, a GBP 250m venture capital fund aiming to discover and develop breakthrough treatments for dementia.

SV Health Managers LLP is Authorised and Regulated by the Financial Conduct Authority (firm reference number 409119).

Further information is available on our website www.svhealthinvestors.com.

Risk Warning

This financial promotion is issued and approved by SV Health Managers LLP ("SVHM"). Notwithstanding that this document is being provided to you as a financial promotion, you should be made aware that the opportunity described in the document is not suitable for all investors. It should not be relied upon to make an investment decision; any such investment decision should be made only on the basis of the fund scheme documents and appropriate professional advice. Nothing in this fact sheet is intended to be construed as: (i) an offer, invitation or inducement to engage in investment activity; (ii) investment advice or (iii) a recommendation.

The value of investments, and the income from them, may go down as well as up, and is not guaranteed, and investors may not get back the full amount invested. Past performance is not a guide to future performance and exchange rate changes may cause the value of overseas investments to rise or fall. Trusts such as the Company are able to borrow to raise further funds. This is generally known as "gearing", this can have the impact of improving returns in rising markets but conversely can increase the decrease in the value of funds in falling markets.

Investors should bear in mind that investment in biotechnology shares can be subject to risks not normally associated with more developed markets or stocks. Investing in the biotechnology sector carries some particular risks and investment in the Company should be regarded both as long term and as carrying a high level of financial risk. In addition, there is no guarantee that the market price of shares in investment trusts will fully reflect their underlying NAV and it is not uncommon for the market price of such shares to trade at a substantial discount to their NAV.

This document has been prepared and is only made available to recipients who may lawfully receive it in accordance with applicable laws, regulations and rules and binding guidance of regulators. Every effort is taken to ensure the accuracy of the data used in this document but no warranties are given. Full details of the Company, including risk warnings, are published in the Investor Disclosure Document and Key Information Document which are available on request and at www.ibtplc.com. SVHM is authorised and regulated by the Financial Conduct Authority.

4