Item 5.02 Departure of Directors or Certain Officers; Election of Directors;


          Appointment of Certain Officers; Compensatory Arrangements of Certain
          Officers.

On November 19, 2021, Peter N. Reikes, a member of the Board of Directors ("Board") and Finance Committee of the Board of Ionis Pharmaceuticals, Inc. (the "Company"), notified the Company that he is resigning from the Company's Board effective November 21, 2021. Mr. Reikes has accepted a position with the U.S. Food and Drug Administration that requires him to step off the Company's Board to avoid a perception of a conflict of interest. The Company thanks Mr. Reikes for his advice and leadership as a member of the Company's Board. The Company wishes Mr. Reikes success in his new endeavor.

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