Item 8.01 Other Events.

On November 24, 2021, Ionis Pharmaceuticals, Inc. issued a press release announcing that Ionis' partner, Pfizer, provided an update on the Phase 2b study of vupanorsen, formerly IONIS-ANGPTL3-LRx.

A copy of this press release is attached as Exhibit 99.1 to this Current Report and incorporated herein by reference.

Item 9.01. Financial Statements and Exhibits.





(d) Exhibits.

Exhibit No.   Description
   99.1       Press Release dated November 24, 2021.

    104       Cover Page Interactive Data File (embedded within the Inline XBRL document).

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