IQVIA announced its strategic collaboration with HealthCore, Inc. to advance real world evidence (RWE) studies with increased quality and efficiency. RWE studies incorporate innovative scientific methods with dynamic data from sources such as electronic medical records, pharmacy and medical claims, laboratory and genomics records, and patient-reported outcomes. The IQVIA HealthCore agreement focuses on improving Real World Data (RWD) breadth and depth, as well as research innovation. Most HealthCore de-identified claims and clinical data have been incorporated into the IQVIA PharMetrics® Plus data source, resulting in a substantial patient volume increase. Voluntary patient participation allows linkage to other supported data sources, allowing a more complete view into the patient healthcare experience. Large data sources are key to answering complex patient research questions on topics such as clinical safety and comparative effectiveness. This innovative research collaboration will focus specifically on real world studies such as external comparators, pragmatic trials, and enriched studies. Enriched study types often combine secondary data sources, along with primary data collection via chart reviews and other forms of physician or opt-in patient data collection, including patient-reported outcomes. With growing regulatory acceptance of RWE in clinical trials, there is increased interest in external comparator studies that utilize real world data sources as comparison arms in single-arm trials. HealthCores patient and physician networks support a more streamlined approach to these studies through chart reviews and information abstraction.