You should read the following discussion and analysis of our financial condition
and results of operations together with our consolidated financial statements
and the related notes included elsewhere in this Annual Report on Form 10-K.
Some of the information contained in this discussion and analysis or set forth
elsewhere in this Annual Report, including information with respect to our plans
and strategy for our business, includes forward-looking statements that involve
risks and uncertainties. You should read the "Risk Factors" section of this
Annual Report for a discussion of important factors that could cause actual
results to differ materially from the results described in or implied by the
forward-looking statements contained in the following discussion and analysis.

                                       46
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Overview



IQVIA is a leading global provider of advanced analytics, technology solutions
and clinical research services to the life sciences industry. IQVIA creates
intelligent connections across all aspects of healthcare through its analytics,
transformative technology, big data resources and extensive domain expertise.
IQVIA Connected Intelligence™ delivers powerful insights with speed and agility
- enabling customers to accelerate the clinical development and
commercialization of innovative medical treatments that improve healthcare
outcomes for patients. With approximately 86,000 employees, we conduct
operations in more than 100 countries.

We are managed through three reportable segments: Technology & Analytics
Solutions, Research & Development Solutions and Contract Sales & Medical
Solutions. Technology & Analytics Solutions provides mission critical
information, technology solutions and real world insights and services to our
life science clients. Research & Development Solutions, which primarily serves
biopharmaceutical clients, provides outsourced clinical research and clinical
trial services. Contract Sales & Medical Solutions provides health care provider
(including contract sales) and patient engagement services to both
biopharmaceutical clients and the broader healthcare market.

For a description of our service offerings within our segments, refer to Part I, Item 1, "Business".



Throughout 2022 we experienced broad, robust demand for all our offerings as
demonstrated by our results for the year ended December 31, 2022, and our
remaining performance obligations of approximately $29.2 billion as of
December 31, 2022. We produced these results in the face of significant
unforeseen challenges presented by the global macro environment including wage
inflation and attrition, general inflation, staff shortages affecting
investigator sites, along with the slow recovery of patient visits. As a
response to these challenges, we have decided to accelerate targeted
productivity initiatives so we can mitigate the impact in 2023. Overall, the
life sciences industry that we serve is a long-cycle business and is well placed
to weather uncertainties.

The COVID-19 pandemic continued to impact operations in 2022. While we expanded
our decentralized clinical trials capabilities and other more remote and
technology-based offerings throughout 2022, due to the progression of the
world's overall response to the pandemic and specifically work related to
clinical development of COVID-19 vaccines, we experienced a decline in revenues
in 2022 from COVID-19 related work. If current trends for the pandemic continue,
we expect to see a continued decline in COVID-19 related work in 2023 compared
to 2022. As of December 31, 2022 COVID-19 related work did not represent a
material amount of our remaining performance obligations.

The Company continues to maintain strong liquidity. As of December 31, 2022,
cash and cash equivalents were $1,216 million and the Company had $425 million
drawn under its $1.5 billion revolving credit facility. As of December 31, 2022,
the Company was in compliance with the financial covenants under its debt
agreements in all material respects and does not have material uncertainty about
ongoing ability to meet the covenants of our credit arrangements.

Industry Outlook

For information about the industry outlook and markets that we operate in, refer to Part I, Item I, "Our Market Opportunity".

Business Combinations



We have completed and will continue to consider strategic business combinations
to enhance our capabilities and offerings in certain areas, including various
individually immaterial acquisitions during the years ended December 31, 2022
and 2021. These transactions were accounted for as business combinations and the
acquired results of operations are included in our consolidated financial
information since the acquisition date. See Note 14 to our audited consolidated
financial statements included elsewhere in this Annual Report on Form 10-K for
additional information with respect to these business combinations.

Sources of Revenues

Total revenues are comprised of revenues from the provision of our services. We do not have any material product revenues.


                                       47
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Costs and Expenses



Our costs and expenses are comprised primarily of our cost of revenues including
reimbursed expenses and selling, general and administrative expenses. Cost of
revenues includes compensation and benefits for billable employees and personnel
involved in production, trial monitoring, data management and delivery, and the
costs of acquiring and processing data for our information offerings; costs of
staff directly involved with delivering technology-related services offerings
and engagements, related accommodations and the costs of data purchased
specifically for technology services engagements; and other expenses directly
related to service contracts such as courier fees, laboratory supplies,
professional services and travel expenses. Reimbursed expenses, which are
included in cost of revenues, are comprised principally of payments to
investigators who oversee clinical trials and travel expenses for our clinical
monitors and sales representatives. Selling, general and administrative expenses
include costs related to sales, marketing and administrative functions
(including human resources, legal, finance, quality assurance, compliance and
general management) for compensation and benefits, travel, professional
services, training and expenses for information technology and facilities. We
also incur costs and expenses associated with depreciation and amortization.

Foreign Currency Translation



In 2022, approximately 30% of our revenues were denominated in currencies other
than the United States dollar, which represents approximately 60 currencies.
Because a large portion of our revenues and expenses are denominated in foreign
currencies and our financial statements are reported in United States dollars,
changes in foreign currency exchange rates can significantly affect our results
of operations. The revenues and expenses of our foreign operations are generally
denominated in local currencies and translated into United States dollars for
financial reporting purposes. Accordingly, exchange rate fluctuations will
affect the translation of foreign results into United States dollars for
purposes of reporting our consolidated results. As a result, we believe that
reporting results of operations that exclude the effects of foreign currency
rate fluctuations on certain financial results can facilitate analysis of period
to period comparisons. This constant currency information assumes the same
foreign currency exchange rates that were in effect for the comparable
prior-year period were used in translation of the current period results. As
such, the differences noted below between reported results of operations and
constant currency information is wholly attributable to the effects of foreign
currency rate fluctuations.

Consolidated Results of Operations

For information regarding our results of operations for our Technology & Analytics Solutions, Research & Development Solutions and Contract Sales & Medical Solutions segments, refer to "Segment Results of Operations" later in this section.

For a discussion of our results of operations comparison for 2021 and 2020, refer to our Annual Report on Form 10-K for the fiscal year ended December 31, 2021 filed on February 16, 2022.



Revenues
                                                                                                                               Change
                                                    Year Ended December 31,                   2022 vs. 2021                          2021 vs. 2020

(dollars in millions)                      2022              2021              2020                  $                  %                   $                   %
Revenues                                $ 14,410          $ 13,874          $ 11,359          $        536              3.9  %       $      2,515              22.1  %



2022 compared to 2021

In 2022, our revenues increased $536 million, or 3.9%, as compared to 2021. This increase was comprised of constant currency revenue growth of approximately $1,084 million, or 7.8%, reflecting a $483 million increase in Technology & Analytics Solutions, a $580 million increase in Research & Development Solutions, and a $21 million increase in Contract Sales & Medical Solutions.


                                       48
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Cost of Revenues, exclusive of Depreciation and Amortization



                                                                       Year Ended December 31,
(dollars in millions)                                         2022               2021               2020
Cost of revenues, exclusive of depreciation and
amortization                                              $   9,382          $   9,233          $   7,500
% of revenues                                                  65.1  %            66.5  %            66.0  %


2022 compared to 2021



When compared to 2021, cost of revenues, exclusive of depreciation and
amortization increased $149 million in 2022, or 1.6%. This increase included a
constant currency increase of approximately $674 million, or 7.3%, comprised of
a $228 million increase in Technology & Analytics Solutions, a $408 million
increase in Research & Development Solutions, and a $38 million increase in
Contract Sales & Medical Solutions.

As a percent of revenues, cost of revenues, exclusive of depreciation and amortization in 2022 decreased compared to 2021.

Selling, General and Administrative Expenses


                                                               Year Ended 

December 31,


     (dollars in millions)                                 2022          

2021 2020


     Selling, general and administrative expenses       $ 2,071       $ 1,964       $ 1,789
     % of revenues                                         14.4  %       14.2  %       15.7  %



2022 compared to 2021

The $107 million increase in selling, general and administrative expenses in
2022 as compared to 2021 included a constant currency increase of approximately
$211 million, or 10.7%, comprised of a $107 million increase in Technology &
Analytics Solutions, a $81 million increase in Research & Development Solutions,
a $8 million increase in Contract Sales & Medical Solutions, and a $15 million
increase in general corporate and unallocated expenses.

Depreciation and Amortization



                                                        Year Ended December 

31,


             (dollars in millions)                  2022          2021      

2020


             Depreciation and amortization       $ 1,130       $ 1,264       $ 1,287
             % of revenues                           7.8  %        9.1  %       11.3  %



The $134 million decrease in depreciation and amortization in 2022 as compared
to 2021 was primarily due to certain intangible assets from the merger between
Quintiles and IMS Health becoming fully amortized in 2021, offset by higher
intangible asset balances as a result of acquisitions occurring in 2021 and
2022, increased amortization due to higher capitalized software balances and
accelerated amortization related to the abandonment of certain internally
developed software assets.

Restructuring Costs

                                                   Year Ended December 31,
                 (in millions)                    2022              2021      2020
                 Restructuring costs      $     28                 $ 20      $ 52



The restructuring costs incurred were due to ongoing efforts to streamline our
global operations and reduce overcapacity to adapt to changing market conditions
and integrate acquisitions. The remaining actions under these plans are expected
to occur throughout 2023 and are expected to consist of consolidating functional
activities, eliminating redundant positions, and aligning resources with
customer requirements.

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Interest Income and Interest Expense


                                                 Year Ended December 31,
                  (in millions)                2022             2021       2020
                  Interest income       $     (13)             $  (6)     $  (6)
                  Interest expense      $     416              $ 375      $ 416

Interest income included interest received primarily from bank balances and investments. The increase is primarily a result of higher deposit rates.



Interest expense during 2022 was higher than 2021 due primarily to higher base
rate interest costs across the floating rate debt portfolio as well as from an
increase in our net debt.

Loss on Extinguishment of Debt


                                                        Year Ended December 

31,


           (in millions)                                2022              

2021 2020


           Loss on extinguishment of debt      $      -                  $ 26      $ 13



During 2021, we recognized a loss on extinguishment of debt of $26 million for
fees and expenses incurred related to the refinancing of our 3.250% Senior Notes
due 2025 and Prior Credit Agreement as discussed further in Note 10 to our
audited consolidated financial statements included elsewhere in this Annual
Report on Form 10-K.

Other expense (income), net
                                                      Year Ended December 31,
             (in millions)                          2022             2021       2020
             Other expense (income), net      $    33              $ (130)     $ (65)

Other expense (income), net for 2022 increased compared to 2021 primarily due to foreign currency losses and losses on investments.

Income Tax Expense


                                                     Year Ended December 

31,


             (dollars in millions)              2022                2021        2020
             Income tax expense             $    260              $ 163       $  72
             Effective income tax rate          19.1   %           14.5  %     19.3  %



In 2022, we recorded a benefit of $6 million related to a 2021 U.S. Federal tax
return position associated with Foreign Derived Intangible Income ("FDII") and
Global Intangible Low-Taxed Income ("GILTI") tax credits. In addition, our
effective tax rate was impacted by changes in the geographical mix of earnings
amongst foreign tax jurisdictions as well as state and local tax rates.

In 2021, we recorded a benefit of $29 million related to a 2020 U.S. Federal tax
return position associated with FDII and GILTI tax credits. Also in 2021, we
recorded a $9 million tax expense as a result of the U.S. Treasury Department
issuing final regulations on foreign tax credits.

Equity in (Losses) Earnings of Unconsolidated Affiliates


                                                                            Year Ended December 31,
(in millions)                                                    2022                 2021                2020
Equity in (losses) earnings of unconsolidated
affiliates                                                  $        (12)         $        6          $        7

Equity in (losses) earnings of unconsolidated affiliates decreased in 2022 compared to 2021 due to the losses in the operations of our unconsolidated affiliates.


                                       50
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Net Income Attributable to Non-controlling Interests


                                                                          Year Ended December 31,
(in millions)                                                   2022                2021               2020

Net income attributable to non-controlling interests $ -

$ (5) $ (29)





Net income attributable to non-controlling interests included Quest Diagnostics
Incorporated's ("Quest") interest in Q2 Solutions. On April 1, 2021 the Company
acquired the 40% non-controlling interest in Q2 Solutions from Quest which
resulted in a decrease in the net income attributable to non-controlling
interests in 2022 compared to 2021. See Note 13 to our audited consolidated
financial statements included elsewhere in this Annual Report on Form 10-K for
additional details regarding this transaction.

Segment Results of Operations

Revenues and profit by segment are as follows:


                                                   Segment Revenues                         Segment Profit
(in millions)                              2022          2021          2020         2022         2021         2020
Technology & Analytics Solutions        $  5,746      $  5,534      $  4,858      $ 1,550      $ 1,458      $ 1,216
Research & Development Solutions           7,921         7,556         5,760        1,695        1,476        1,048
Contract Sales & Medical Solutions           743           784           741           42           75           57
Total                                     14,410        13,874        11,359        3,287        3,009        2,321
General corporate and unallocated                                                    (330)        (332)        (251)
Depreciation and amortization                                                      (1,130)      (1,264)      (1,287)

Restructuring costs                                                                   (28)         (20)         (52)
Consolidated                            $ 14,410      $ 13,874      $ 11,359      $ 1,799      $ 1,393      $   731



Certain costs are not allocated to our segments and are reported as general
corporate and unallocated expenses. These costs primarily consist of stock-based
compensation and expenses related to integration activities and acquisitions. We
also do not allocate depreciation and amortization or impairment charges to our
segments.

Technology & Analytics Solutions



                                                 Year Ended December 31,                                               Change
(dollars in millions)                     2022              2021             2020                 2022 vs. 2021                      2021 vs. 2020
Revenues                              $   5,746          $ 5,534          $ 4,858          $    212               3.8%       $    676

13.9%


Cost of revenues, exclusive of
depreciation
  and amortization                        3,348               3,278            2,900                70             2.1               378              13.0
Selling, general and
administrative expenses                     848                 798              742                50             6.3                56               7.5
Segment profit                        $   1,550          $ 1,458          $ 1,216          $     92               6.3%       $    242                19.9%



Revenues

2022 compared to 2021

Technology & Analytics Solutions' revenues were $5,746 million in 2022, an
increase of $212 million, or 3.8%, over 2021. This increase was comprised of
constant currency revenue growth of approximately $483 million, or 8.7%,
reflecting revenue growth across all regions. The constant currency revenue
growth was primarily driven by an increase in real world services, and to a
lesser extent by increases in consulting and analytical services and information
and technology services.

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Cost of Revenues, exclusive of Depreciation and Amortization

2022 compared to 2021



Technology & Analytics Solutions' cost of revenues, exclusive of depreciation
and amortization, was $3,348 million in 2022, an increase of $70 million over
2021. This increase was comprised of constant currency increase of approximately
$228 million, or 7.0%, reflecting an increase in compensation and related
expenses to support revenue growth.

Selling, General and Administrative Expenses

2022 compared to 2021



Technology & Analytics Solutions' selling, general and administrative expenses
increased $50 million in 2022 as compared to 2021. This increase was comprised
of a constant currency increase of approximately $107 million, or 13.4%,
reflecting an increase in compensation and related expenses.

Research & Development Solutions



                                                 Year Ended December 31,                                                Change
(dollars in millions)                     2022              2021             2020                  2022 vs. 2021                       2021 vs. 2020
Revenues                              $   7,921          $ 7,556          $ 5,760          $    365                 4.8%       $  1,796

31.2%


Cost of revenues, exclusive of
depreciation
  and amortization                        5,395               5,303            3,974                92               1.7             1,329              33.4
Selling, general and
administrative expenses                     831                 777              738                54               6.9                39               5.3
Segment profit                        $   1,695          $ 1,476          $ 1,048          $    219                14.8%       $    428                40.8%



Backlog

Research & Development Solutions' contracted backlog increased from
$24.8 billion as of December 31, 2021 to $27.2 billion as of December 31, 2022
and we expect approximately $7.3 billion of this backlog to convert to revenues
in the next 12 months. Contracted backlog was $22.6 billion as of December 31,
2020.

Backlog represents, at a particular point in time, future revenues from work not yet completed or performed under signed contracts. Once work begins on a project, revenues are recognized over the duration of the project.



We believe that backlog is an indicator of future revenues but the timing of
revenues will be affected by a number of factors, including the variable size
and duration of projects, many of which are performed over several years,
cancellations, and changes to the scope of work during the course of projects.
Projects that have been delayed remain in backlog, but the timing of the
revenues generated may differ from the timing originally expected. Additionally,
projects may be terminated or delayed by the customer or delayed by regulatory
authorities. In the event that a client cancels a contract, we typically would
be entitled to receive payment for all services performed up to the cancellation
date and subsequent client-authorized services related to winding down the
canceled project. For more details regarding risks related to our backlog, see
Part I, Item IA, "Risk Factors-Risks Related to our Business-The relationship of
backlog to revenues varies over time."

Revenues

2022 compared to 2021



Research & Development Solutions' revenues were $7,921 million in 2022, an
increase of $365 million, or 4.8%, over 2021. This increase was comprised of
constant currency revenue growth of approximately $580 million, or 7.7%,
reflecting revenue growth in the Europe and Africa and Asia-Pacific regions,
partially offset by a decrease in COVID-19 related work in the Americas region.
The constant currency revenue growth was primarily the result of volume-related
increases in clinical services and to a lesser extent from volume-related
increases in lab testing.


                                       52
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Cost of Revenues, exclusive of Depreciation and Amortization

2022 compared to 2021



Research & Development Solutions' cost of revenues, exclusive of depreciation
and amortization, increased $92 million, or 1.7%, in 2022 as compared to 2021.
This increase included a constant currency increase of approximately $408
million, or 7.7%, reflecting an increase in compensation and related expenses as
a result of volume-related increases in clinical services and lab testing.


Selling, General and Administrative Expenses

2022 compared to 2021



Research & Development Solutions' selling, general and administrative expenses
increased $54 million, or 6.9%, in 2022 as compared to 2021, which included a
constant currency increase of approximately $81 million, or 10.4%, reflecting an
increase in compensation and related expenses.

Contract Sales & Medical Solutions


                                                Year Ended December 31,                                                  Change
(dollars in millions)                     2022             2021            2020                  2022 vs. 2021                          2021 vs. 2020
Revenues                              $     743          $  784          $  741          $    (41)              (5.2)%       $           43             

5.8%


Cost of revenues, exclusive of
depreciation
  and amortization                          639             652             626               (13)               (2.0)                   26                  4.2
Selling, general and
administrative expenses                      62              57              58                 5                  8.8                   (1)               (1.7)
Segment profit                        $      42          $   75          $   57          $    (33)             (44.0)%       $           18                31.6%



Revenues

2022 compared to 2021

Contract Sales & Medical Solutions' revenues were $743 million in 2022, a
decrease of $41 million, or 5.2%, over 2021. This decrease included constant
currency revenue growth of approximately $21 million, or 2.7%, reflecting
revenue growth primarily in the Europe and Africa region. The constant currency
revenue growth was largely due to a volume-related increase in services
performed.

Cost of Revenues, exclusive of Depreciation and Amortization

2022 compared to 2021



Contract Sales & Medical Solutions' cost of revenues, exclusive of depreciation
and amortization, decreased $13 million, or 2.0%, in 2022 as compared to 2021.
This decrease included a constant currency increase of approximately $38
million, or 5.8%, reflecting an increase in compensation and related expenses
and reimbursed expenses.

Selling, General and Administrative Expenses

2022 compared to 2021



Contract Sales & Medical Solutions' selling, general and administrative expenses
increased $5 million, or 8.8%, in 2022 as compared to 2021. This increase
included a constant currency increase of approximately $8 million, or 14.0%,
reflecting an increase in compensation and related expenses and IT-related
expenses.

                                       53
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Liquidity and Capital Resources

Overview



We assess our liquidity in terms of our ability to generate cash to fund our
operating, investing and financing activities. Our principal source of liquidity
is operating cash flows. In addition to operating cash flows, other significant
factors that affect our overall management of liquidity include: capital
expenditures, acquisitions, investments, debt service requirements, equity
repurchases, adequacy of our revolving credit and receivables financing
facilities, and access to the capital markets.

We manage our worldwide cash requirements by monitoring the funds available
among our subsidiaries and determining the extent to which those funds can be
accessed on a cost-effective basis. The repatriation of cash balances from
certain of our subsidiaries could have adverse tax consequences; however, those
balances are generally available without legal restrictions to fund ordinary
business operations. We have and expect to transfer cash from those subsidiaries
to the United States and to other international subsidiaries when it is cost
effective to do so.

We had a cash balance of $1,216 million as of December 31, 2022 ($349 million of which was in the United States), a decrease from $1,366 million as of December 31, 2021.



Based on our current operating plan, we believe that our available cash and cash
equivalents, future cash flows from operations and our ability to access funds
under our revolving credit and receivables financing facilities will enable us
to fund our operating requirements, capital expenditures, contractual
obligations, and meet debt obligations for at least the next 12 months. We
regularly evaluate our debt arrangements, as well as market conditions, and from
time to time we may explore opportunities to modify our existing debt
arrangements or pursue additional financing arrangements that could result in
the issuance of new debt securities by us or our affiliates. We may use our
existing cash, cash generated from operations or dispositions of assets or
businesses and/or proceeds from any new financing arrangements or issuances of
debt or equity securities to repay or reduce some of our outstanding
obligations, to repurchase shares from our stockholders or for other purposes.
As part of our ongoing business strategy, we also continually evaluate new
acquisition, expansion and investment possibilities or other strategic growth
opportunities, as well as potential dispositions of assets or businesses, as
appropriate, including dispositions that may cause us to recognize a loss on
certain assets. Should we elect to pursue any such transaction, we may seek to
obtain debt or equity financing to facilitate those activities. Our ability to
enter into any such potential transactions and our use of cash or proceeds is
limited to varying degrees by the terms and restrictions contained in our
existing debt arrangements. We cannot provide assurances that we will be able to
complete any such financing arrangements or other transactions on favorable
terms or at all.

Equity Repurchase Program



On February 10, 2022 the Board increased the stock repurchase authorization
under the Company's equity repurchase program (the "Repurchase Program") with
respect to the repurchase of the Company's common stock by an additional
$2.0 billion, which increased the total amount that has been authorized under
the Repurchase Program to $9.725 billion since the program's inception in
October 2013. The Repurchase Program does not obligate the Company to repurchase
any particular amount of common stock, and it may be modified, extended,
suspended or discontinued at any time.

As of December 31, 2022, the Company had remaining authorization to repurchase
up to approximately $1.36 billion of its common stock under the Repurchase
Program. In addition, from time to time, the Company has repurchased and may
continue to repurchase common stock through private or other transactions
outside of the Repurchase Program.

Additional information regarding the Repurchase Program is presented in Part II,
Item 5 "Market for Registrant's Common Equity, Related Stockholder Matters and
Issuer Purchases of Equity Securities" and Note 13 to our audited consolidated
financial statements included elsewhere in this Annual Report on Form 10-K.

Debt



As of December 31, 2022, we had $12.8 billion of total indebtedness, excluding
$1.1 billion of additional available borrowings under our revolving credit
facility. See Note 10 to our audited consolidated financial statements included
elsewhere in this Annual Report on Form 10-K for additional details regarding
our credit arrangements.

                                       54
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Our long-term debt arrangements contain customary restrictive covenants and, as of December 31, 2022, we believe we were in compliance with our restrictive covenants in all material respects.

Senior Secured Credit Facilities



On June 16, 2022, the Company entered into Amendment No. 1 to the Company's
Fifth Amended and Restated Credit Agreement (as amended, the "Fifth Amended and
Restated Credit Agreement") to borrow $1,250 million in Additional Term A Loans.
The proceeds from the Additional Term A Loans were used to repay approximately
$950 million of outstanding revolving credit loans under the Company's senior
secured credit facilities and for general corporate purposes.

On October 13, 2022, the Company elected to prepay $510 million, the entire outstanding balance, of its U.S. Dollar Term B Loan due 2024.



As of December 31, 2022, the Fifth Amended and Restated Credit Agreement
provided financing through several senior secured credit facilities
(collectively, the "senior secured credit facilities") of up to approximately
$7,637 million, which consisted of $6,562 million principal amounts of debt
outstanding and $1,070 million of available borrowing capacity on the revolving
credit facility and standby letters of credit, with a total capacity of $1,500
million. The revolving credit facility is comprised of a $675 million senior
secured revolving facility available in U.S. dollars, a $600 million senior
secured revolving facility available in U.S. dollars, Euros, Swiss Francs and
other foreign currencies, and a $225 million senior secured revolving facility
available in U.S. dollars and Yen. The term A loans and revolving credit
facility under the Fifth Amended and Restated Credit Agreement mature in August
2026, the Additional Term A Loans mature June 2027, while the term B loans under
the Fifth Amended and Restated Credit Agreement mature in 2024 and 2025. We are
required to make scheduled quarterly payments on the term A loans and the
Additional Term A Loans equal to 1.25% of the original principal amount, with
the remaining balance paid at maturity. In addition, beginning with fiscal year
ending December 31, 2017, we were required to apply 50% of excess cash flow (as
defined in the Fifth Amended and Restated Credit Agreement), subject to a
reduction to 25% or 0% depending upon our senior secured first lien net leverage
ratio, for prepayment of the term loans, with any such prepayment to be applied
toward principal payments due in subsequent quarters. We are also required to
pay an annual commitment fee that ranges from 0.20% to 0.35% in respect of any
unused commitments under the revolving credit facility. The senior secured
credit facilities are collateralized by substantially all of our assets and the
assets of our material domestic subsidiaries including 100% of the equity
interests of substantially all of our material domestic subsidiaries and 66% of
the equity interests of substantially all of our first-tier material foreign
subsidiaries and their domestic subsidiaries.

For information regarding the senior secured credit facilities, see Note 10 to
our audited consolidated financial statements included elsewhere in this Annual
Report on Form 10-K.

Receivables Financing Facility



For information regarding the receivables financing facility, see Note 10 to our
audited consolidated financial statements included elsewhere in this Annual
Report on Form 10-K. As of December 31, 2022, no additional amounts of revolving
loan commitments were available under the receivables financing facility.

Years ended December 31, 2022, 2021 and 2020

Cash Flow from Operating Activities


                                                       Year Ended December 

31,


(in millions)                                      2022          2021       

2020

Net cash provided by operating activities $ 2,260 $ 2,942 $ 1,959





                                       55
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2022 compared to 2021



Cash provided by operating activities decreased $682 million in 2022 as compared
to 2021. The decrease is primarily due to a decrease in cash from unearned
income ($560 million) and accounts receivable and unbilled services
($283 million) and an increase in cash used for income tax and other payables
($126 million), offset by a decrease in cash for accounts payable and accrued
expenses ($183 million), an increase in cash-related net income ($82 million)
and less cash used for prepaid expenses and other assets ($22 million).

Cash Flow from Investing Activities


                                                             Year Ended 

December 31,


         (in millions)                                   2022          

2021 2020

Net cash used in investing activities $ (2,006) $ (2,103) $ (796)





2022 compared to 2021

Cash used in investing activities decreased $97 million in 2022 as compared to
2021. The decrease was primarily driven by less cash used for the acquisition of
businesses, net of cash acquired ($143 million), a decrease in purchase of
marketable securities ($5 million) and an increase in cash from other sources
($3 million), offset by an increase in acquisitions of property, equipment, and
software ($34 million), an increase in investments in unconsolidated affiliates
($15 million) and a decrease in net proceeds from the sale of equity securities
($5 million).

Cash Flow from Financing Activities


                                                     Year Ended December 

31,


(in millions)                                    2022            2021       

2020

Net cash used in financing activities $ (329) $ (1,235) $ (217)





2022 compared to 2021

Cash used in financing activities decreased $906 million in 2022 as compared to
2021, primarily due to a decrease in debt payments ($1,457 million), the absence
of cash payments for the Company's acquisition of Quest's non-controlling
interest in Q2 Solutions ($758 million), a decrease in cash used in repayments
of revolving credit facilities, net of proceeds ($115 million), a decrease in
cash payments on contingent consideration and deferred purchase price accruals
($16 million), offset by an increase in cash used to repurchase common stock
($762 million), a decrease in cash provided by proceeds from debt issuances, net
of payment of debt issuance costs ($666 million) and an increase in cash
payments related to employee stock option plans ($12 million).

Contingencies



We are exposed to certain known contingencies that are material to our
investors. The facts and circumstances surrounding these contingencies and a
discussion of their effect on us are included in Note 12 to our audited
consolidated financial statements included elsewhere in this Annual Report on
Form 10-K. These contingencies may have a material effect on our liquidity,
capital resources or results of operations. In addition, even where our accruals
are adequate, the incurrence of any of these liabilities may have a material
effect on our liquidity and the amount of cash available to us for other
purposes.

We believe that we have made appropriate arrangements in respect of the future
effect on us of these known contingencies. We also believe that the amount of
cash available to us from our operations, together with cash from financing,
will be sufficient for us to pay any known contingencies as they become due
without materially affecting our ability to conduct our operations and invest in
the growth of our business.

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Off-Balance Sheet Arrangements

We do not have any material off-balance sheet arrangements.

Contractual Obligations and Commitments

Below is a summary of our future payment commitments by year under contractual obligations as of December 31, 2022:



(in millions)                                    2023            2024-2025           2026-2027           Thereafter            Total

Long-term debt, including interest (1) $ 723 $ 5,514

       $    6,026          $     2,596          $ 14,859
Operating leases                                  123                 173                  66                   38               400
Finance leases                                     11                  25                  26                  295               357
Data acquisition                                  609                 518                 204                    6             1,337
Purchase obligations (2)                           79                  24                   9                   11               123
Commitments to unconsolidated
affiliates (3)                                      -                   -                   -                    -                 -
Benefit obligations (4)                            32                  28                  31                   81               172
Uncertain income tax positions (5)                 22                  20                  15                    -                57
Total                                         $ 1,599          $    6,302          $    6,377          $     3,027          $ 17,305



(1)  Interest payments on our debt are based on the interest rates in effect as
of December 31, 2022.
(2)  Purchase obligations are defined as agreements to purchase goods or
services that are enforceable and legally binding and that specify all
significant terms, including fixed or minimum quantities to be purchased, fixed,
minimum or variable pricing provisions and the approximate timing of the
transactions.
(3)  We are currently committed to invest $249 million in private equity funds.
As of December 31, 2022, we have funded approximately $119 million of these
commitments and we have approximately $130 million remaining to be funded which
has not been included in the above table as we are unable to predict when these
commitments will be paid.
(4)  Amounts represent expected future benefit payments for our pension and
postretirement benefit plans, as well as expected contributions for 2023 for our
funded pension benefit plans. We made cash contributions totaling approximately
$35 million to our defined benefit plans in 2022, and we estimate that we will
make contributions totaling approximately $32 million to our defined benefit
plans in 2023. Due to the potential impact of future plan investment
performance, changes in interest rates, changes in other economic and
demographic assumptions and changes in legislation in foreign jurisdictions, we
are not able to reasonably estimate the timing and amount of contributions that
may be required to fund our defined benefit plans for periods beyond 2023.
(5)  As of December 31, 2022, our liability related to uncertain income tax
positions was approximately $136 million, $79 million of which has not been
included in the above table as we are unable to predict when these liabilities
will be paid due to the uncertainties in the timing of the settlement of the
income tax positions.

Application of Critical Accounting Policies and Estimates



Note 1 to the audited consolidated financial statements provided elsewhere in
this Annual Report on Form 10-K describes the significant accounting policies
used in the preparation of the consolidated financial statements. The
preparation of our consolidated financial statements requires management to make
estimates and assumptions that affect the reported amounts of assets and
liabilities, and the disclosure of contingent assets and liabilities at the date
of the financial statements, as well as the reported amounts of revenues and
expenses during the period. Our estimates are based on historical experience and
various other assumptions we believe are reasonable under the circumstances. We
evaluate our estimates on an ongoing basis and make changes to the estimates and
related disclosures as experience develops or new information becomes known.
Actual results may differ from those estimates.

We believe the following critical accounting policies affect our more significant judgments and estimates used in the preparation of our consolidated financial statements.


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Revenue Recognition



The majority of the Company's contracts within the Research & Development
Solutions segment are service contracts for clinical research that represent a
single performance obligation. The Company provides a significant integration
service resulting in a combined output, which is clinical trial data that meets
the relevant regulatory standards and can be used by the customer to progress to
the next phase of a clinical trial or solicit approval of a treatment by the
applicable regulatory body. The performance obligation is satisfied over time as
the output is captured in data and documentation that is available for the
customer to consume over the course of the arrangement and furthers progress of
the clinical trial. The Company recognizes revenues over time using a cost-based
input method since there is no single output measure that would fairly depict
the transfer of control over the life of the performance obligation. Progress on
the performance obligation is measured by the proportion of actual costs
incurred to the total costs expected to complete the contract. Costs included in
the measure of progress include direct labor and third-party costs (such as
payments to investigators and other reimbursed expenses for the Company's
clinical monitors). This cost-based method of revenue recognition requires the
Company to make estimates of costs to complete its projects on an ongoing basis.
Significant judgment is required to evaluate assumptions related to these
estimates. The effect of revisions to estimates related to the transaction price
or costs to complete a project are recorded in the period in which the estimate
is revised. Most contracts may be terminated upon 30 to 90 days' notice by the
customer; however, in the event of termination, most contracts require payment
for services rendered through the date of termination, as well as for subsequent
services rendered to close out the contract. A hypothetical increase of one
percent in the estimated costs to complete these service contracts as of
December 31, 2022 could have resulted in approximately a one percent reduction
in total revenues for the year ended December 31, 2022, whereas, a hypothetical
decrease of one percent could have resulted in a one percent increase in total
revenues.

Income Taxes

The provision for income taxes includes federal, state, local and foreign taxes.
Income taxes are accounted for under the asset and liability method. Deferred
tax assets and liabilities are recognized for the estimated future tax
consequences of temporary differences between the financial statement carrying
amounts and their respective tax bases. Deferred tax assets and liabilities are
measured using enacted tax rates expected to apply to taxable income in the year
in which the temporary differences are expected to be recovered or settled. We
record U.S. deferred taxes based on the Federal corporate income tax rate of
21%, We account for tax related to GILTI as a period cost when incurred.
Recognition of deferred income tax assets is based on management's belief that
it is more likely than not that the income tax benefit associated with certain
temporary differences, income tax operating loss, capital loss carryforwards,
and income tax credits, will be realized. We recorded a valuation allowance to
reduce our deferred income tax assets for those deferred income tax items for
which it was more likely than not that realization would not occur. We
determined the amount of the valuation allowance based, in part, on our
assessment of future taxable income and in light of our ongoing income tax
strategies. If our estimate of future taxable income or tax strategies changes
at any time in the future, we would record an adjustment to our valuation
allowance. Recording such an adjustment could have a material effect on our
financial condition or results of operations.

Income tax expense is based on the distribution of profit before income tax
among the various taxing jurisdictions in which we operate, adjusted as required
by the income tax laws of each taxing jurisdiction. Changes in the distribution
of profits and losses among taxing jurisdictions may have a significant impact
on our effective income tax rate. We do not consider the undistributed earnings
of our foreign subsidiaries to be indefinitely reinvested outside of the United
States.

Business Combinations and Goodwill



We use the acquisition method to account for business combinations, and
accordingly, the identifiable assets acquired, the liabilities assumed and any
non-controlling interests in the acquiree are recorded at their estimated fair
values on the date of the acquisition. We use significant judgments, estimates
and assumptions in determining the estimated fair value of assets acquired,
liabilities assumed and non-controlling interests including expected future cash
flows and discount rates that reflect the risk associated with the expected
future cash flows and estimated useful lives.

We have recorded and allocated to our reporting units the excess of the purchase
price over the fair value of the net assets acquired, known as goodwill. The
recoverability of goodwill is evaluated annually for impairment, or if and when
events or circumstances indicate a possible impairment. We perform our annual
goodwill impairment evaluation as of July 31. The impairment analysis requires
significant judgments, estimates and assumptions, including those related to
macroeconomic conditions, industry and market considerations, cost factors,
financial performance, fair value history and other company specific events. For
the years ended December 31, 2022, 2021 and 2020, the Company determined that
there was no impairment of goodwill.
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We review the carrying values of other identifiable intangible assets if the
facts and circumstances indicate a possible impairment. Any future impairment
could have a material adverse effect on our financial condition or results of
operations.

Stock-based Compensation

We measure compensation cost for stock-based payment awards (stock options and
stock appreciation rights) granted to employees and non-employee directors at
fair value using the Black-Scholes-Merton option-pricing model. Stock-based
compensation expense includes stock-based awards granted to employees and
non-employee directors and has been reported in selling, general and
administrative expenses in our consolidated statements of income based upon the
classification of the individuals who were granted stock-based awards.

The Black-Scholes-Merton option-pricing model requires the use of subjective
assumptions, including share price volatility, the expected life of the award,
risk-free interest rate and the fair value of the underlying common shares on
the date of grant. In developing our assumptions, we take into account the
following:

•We calculate expected volatility based on an analysis of the historical
volatility of the Company's stock since the Merger in October 2016 and reported
data for selected reasonably similar publicly traded companies for which the
historical information is available. We plan to continue to use an analysis that
incorporates the selected reasonably similar publicly traded companies
volatility information and the historical volatility of our common shares to
measure expected volatility for future award grants;

•We determine the risk-free interest rate by reference to implied yields available from United States Treasury securities with a remaining term equal to the expected life assumed at the date of grant;

•We estimate the dividend yield to be zero as we do not currently anticipate paying any future dividends;

•We estimate the average expected life of the award based on our historical experience; and

•We estimate forfeitures based on our historical analysis of actual forfeitures.



The Company accounts for its stock-based compensation for performance awards
related to compound annual earnings per share ("EPS") growth over a three year
period based on the closing market price of the Company's common stock on the
date of grant, and for performance awards related to relative total shareholder
return ("TSR") based on a Monte Carlo simulation model. The Company records the
expense amount of the EPS awards based on its estimates of the likelihood that
the various performance targets will be achieved. The estimates are assessed on
a quarterly basis. For the TSR awards the Company records the expense amount
evenly over the service period.

Pensions and Other Postretirement Benefits



We provide retirement benefits to certain employees, including defined benefit
pension plans and postretirement medical plans. The determination of benefit
obligations and expense is based on actuarial models. In order to measure
benefit costs and obligations using these models, critical assumptions are made
with regard to the discount rate, expected return on plan assets, cash balance
crediting rate, lump sum conversion rate and the assumed rate of compensation
increases. In addition, retiree medical care cost trend rates are a key
assumption used exclusively in determining costs for our postretirement health
care and life insurance benefit plans.

Recently Issued Accounting Standards



Information relating to recently issued accounting standards is included in Note
1 to our audited consolidated financial statements included elsewhere in this
Annual Report on Form 10-K.

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