Saskatoon - IsoEnergy Ltd. ('IsoEnergy' or the 'Company') (TSXV: ISO; OTCQX: ISENF) is pleased to provide an update on winter 2022 exploration activities on the 100% owned Larocque East, Geiger, Hawk and Ranger projects in the eastern Athabasca Basin.

Larocque East hosts the Hurricane Zone ('Hurricane' or the 'Project'), a high-grade uranium discovery located in the Eastern Athabasca Basin of Saskatchewan. Winter 2022 drilling at Hurricane has now concluded and advanced planning is underway for the follow-up summer program.

Highlights

30 drill holes totaling 12,147m completed at Larocque East; 36km of conductor strike mapped in two target areas at Geiger, and Ground geophysical surveys completed at Ranger and Hawk.

Tim Gabruch, President and Chief Executive Officer commented: 'IsoEnergy has successfully completed the winter drill program at Larocque East, and significantly advanced the understanding of Hurricane's current size and scope. Assay results are pending and based on these winter drill results at Larocque East and forthcoming geophysical survey results, planning is well underway for an upcoming summer exploration program.'

Andy Carmichael, Vice President of Exploration commented: 'During the winter season, we continued to advance the Project while developing a pipeline of drill-ready projects and targets. At Larocque East, drilling evaluated Hurricane for the potential for additional significant mineralization as well as systematically explored the highly prospective Larocque Lake conductive trend. Concurrently, geophysical surveying has been completed at Geiger, Ranger and Hawk and successfully generated quality drill targets for future drill programs.'

About IsoEnergy

IsoEnergy is a well-funded uranium exploration and development company with a portfolio of prospective projects in the eastern Athabasca Basin in Saskatchewan, Canada. The Company recently discovered the high-grade Hurricane Zone of uranium mineralization on its 100% owned Larocque East property in the Eastern Athabasca Basin. IsoEnergy is led by a Board and Management team with a track record of success in uranium exploration, development, and operations. The Company was founded and is supported by the team at its major shareholder, NexGen Energy Ltd.

Contact:

Tim Gabruch

Tel: +1 306-261-6284

Email: info@isoenergy.ca

Web: www.isoenergy.ca

This news release shall not constitute an offer to sell or a solicitation of any offer to buy any securities, nor shall there be any sale of any securities in any jurisdiction in which such offer, solicitation or sale would be unlawful. The securities referenced herein have not been, nor will they be, registered under the United States Securities Act of 1933, as amended (the 'U.S. Securities Act'), and such securities may not be offered or sold within the United States absent registration under the U.S. Securities Act or an applicable exemption from the registration requirements thereunder.

Forward-Looking Information

The information contained herein contains 'forward-looking statements' within the meaning of the United States Private Securities Litigation Reform Act of 1995 and 'forward-looking information' within the meaning of applicable Canadian securities legislation. 'Forward-looking information' includes, but is not limited to, statements with respect to the activities, events or developments that the Company expects or anticipates will or may occur in the future, including, without limitation, planned exploration activities. Generally, but not always, forward-looking information and statements can be identified by the use of words such as 'plans', 'expects', 'is expected', 'budget', 'scheduled', 'estimates', 'forecasts', 'intends', 'anticipates', or 'believes' or the negative connotation thereof or variations of such words and phrases or state that certain actions, events or results 'may', 'could', 'would', 'might' or 'will be taken', 'occur' or 'be achieved' or the negative connotation thereof.

Such forward-looking information and statements are based on numerous assumptions, including among others, that the results of planned exploration activities are as anticipated, the price of uranium, the anticipated cost of planned exploration activities, that general business and economic conditions will not change in a material adverse manner, that financing will be available if and when needed and on reasonable terms, that third party contractors, equipment and supplies and governmental and other approvals required to conduct the Company's planned exploration activities will be available on reasonable terms and in a timely manner. Although the assumptions made by the Company in providing forward-looking information or making forward-looking statements are considered reasonable by management at the time, there can be no assurance that such assumptions will prove to be accurate.

Forward-looking information and statements also involve known and unknown risks and uncertainties and other factors, which may cause actual events or results in future periods to differ materially from any projections of future events or results expressed or implied by such forward-looking information or statements, including, among others: negative operating cash flow and dependence on third party financing, uncertainty of additional financing, no known mineral reserves or resources, the limited operating history of the Company, the influence of a large shareholder, alternative sources of energy and uranium prices, aboriginal title and consultation issues, reliance on key management and other personnel, actual results of exploration activities being different than anticipated, changes in exploration programs based upon results, availability of third party contractors, availability of equipment and supplies, failure of equipment to operate as anticipated; accidents, effects of weather and other natural phenomena and other risks associated with the mineral exploration industry, environmental risks, changes in laws and regulations, community relations and delays in obtaining governmental or other approvals.

Although the Company has attempted to identify important factors that could cause actual results to differ materially from those contained in the forward-looking information or implied by forward-looking information, there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no assurance that forward-looking information and statements will prove to be accurate, as actual results and future events could differ materially from those anticipated, estimated or intended. Accordingly, readers should not place undue reliance on forward-looking statements or information. The Company undertakes no obligation to update or reissue forward-looking information as a result of new information or events except as required by applicable securities laws

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