Japan Tobacco Inc. (JT) (TSE:2914) and Torii Pharmaceutical Co., Ltd. (Torii) (TSE:4551) announced that ENAROY Tablets 2 mg and 4 mg (generic name: enarodustat) (hereinafter 'ENAROY'), a hypoxia inducible factor prolyl hydroxylase (HIF-PH) inhibitor, have been listed on the Japanese National Health Insurance (NHI) drug price list as of today.
On September 25, 2020, JT received manufacturing and marketing approval of ENAROY in Japan for an indication of anemia associated with chronic kidney disease (CKD) . Torii plans to launch ENAROY in Japan on December 8, 2020.
ENAROY is an orally-active HIF-PH inhibitor that promotes erythropoiesis by accelerating the endogenous production of erythropoietin (EPO) and controlling the expression of molecules responsible for iron metabolism. The Phase 3 clinical studies confirmed the efficacy and safety of ENAROY in anemic patients with CKD, including non-dialysis patients and those receiving peritoneal dialysis or hemodialysis
JT and Torii expect ENAROY to be a new option for the treatment of anemia associated with CKD in Japan.
ABOUT Anemia Associated with CKD
Anemia is one of the complications in CKD patients. The major cause of anemia in patients with CKD is considered to be a decreased ability to produce EPO in the kidney associated with renal dysfunction. Insufficient oxygen supply due to decreased erythrocyte counts associated with anemia decreases the energy production in organs and induces reduction in mobility and activities in daily life, which leads to a poor quality of life.
Japan Tobacco Inc. is a leading international tobacco company with operations in more than 130 countries. With approximately 62,000 employees, it manufactures and sells some of the world's best-known brands including Winston, Camel, MEVIUS and LD. The JT Group is committed to investing in Reduced-Risk Products (RRP) and currently markets its tobacco vapor products under its Ploom brand and various e-cigarette products under its Logic brand. The Group is also present in the pharmaceutical and processed food businesses.
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