NJ Biopharmaceuticals LLC (NJ Bio) is procuring an 800 MHz NMR spectrometer with a cryogenic probe from JEOL. As part of this collaboration, NJ Bio will contribute its expertise in antibody drug conjugates, oligonucleotide conjugates, and other chemistries to develop platform solutions for its drug discovery clients - in particular, a platform for using NMR-derived structural information to optimize Targeted Protein Degraders (TPDs). JEOL has world-class capability in NMR and will provide technical expertise to maximize the performance of the 800 MHz NMR in these drug discovery applications.

JEOL's 800 MHz NMR will provide increased resolution, sensitivity, and precision beyond what is currently possible with NJ Bio's two 500 MHz and one 300 MHz spectrometers. These advancements will allow the study of larger proteins, RNA, and other biomolecules, and allow innovative approaches to studying ligand binding, dynamics, refolding, and the attachment of modifiers to antibodies. The enhanced sensitivity will make possible the study of difficult proteins that must be kept at low concentration due to solubility constraints.

While the collaboration is expected to be a win-win for NJ Bio and JEOL, the true beneficiaries of this effort will be the clients of both companies. With this robust collaboration, NJ Bio will develop innovative platform BioNMR solutions, and JEOL will optimize and expand the utilization of 800 MHz NMR. As these platform solutions are established, NJ Bio will roll out enhanced NMR services to clients and will be able to accelerate clients' drug discovery programs.