A new study published in the British Journal of Clinical Pharmacology provides insights on how common hospitalized patients develop liver injury from taking different medications.
When investigators analyzed the records of 156,570 hospitalized patients, they found 499 cases of drug-induced liver injury (DILI), for an incidence of 0.32%. Anti-infective agents, cancer medications, and nonsteroidal anti-inflammatory drugs were the major categories of drugs causing DILI, and the highest incidence was due to voriconazole (an antifungal medication). Patients with high cholesterol, cardiovascular disease, pre-existing liver disease, and prior surgeries faced a higher risk of DILI.
'We have carried out DILI-related real-world study with the help of information technology to provide a more accurate reference for safe and rational drug use,' said corresponding author DaiHong Guo, of the Chinese People's Liberation Army General Hospital, in Beijing.
Link to Study: https://onlinelibrary.wiley.com/doi/10.1111/bcp.14847
Published on behalf of the British Pharmacological Society, the British Journal of Clinical Pharmacology features papers and reports on all aspects of drug action in humans: review articles, mini review articles, original papers, commentaries, editorials and letters. The Journal enjoys a wide readership, bridging the gap between the medical profession, clinical research and the pharmaceutical industry. It also publishes research on new methods, new drugs and new approaches to treatment. The Journal is recognised as one of the leading publications in its field. It is online only, publishes open access research through its OnlineOpen programme and is published monthly.
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John Wiley & Sons Inc. published this content on 05 May 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 05 May 2021 05:08:02 UTC.