Certain Stock Options of Karuna Therapeutics, Inc. are subject to a Lock-Up Agreement Ending on 30-MAY-2021. These Stock Options will be under lockup for 90 days starting from 1-MAR-2021 to 30-MAY-2021. Details: The company's executive officers, directors and certain of stockholders have agreed with the underwriters, subject to certain exceptions, not to dispose of or hedge any of common stock or securities convertible into or exchangeable for shares of common stock during the period from the date of this prospectus supplement continuing through the date 90 days, in the case of executive officers and directors, 60 days, and 30 days with respect to certain affiliated funds, after the date of this prospectus supplement, except with the prior written consent of Goldman Sachs & Co. LLC and J.P. Morgan Securities LLC.