Item 7.01 Regulation FD Disclosure.

As previously announced, Karyopharm Therapeutics Inc. (the "Company") will host a virtual Investor Day today, Wednesday, December 8, 2021 from 10:00 a.m. to 12:30 p.m. ET. The slides accompanying the presentations can be viewed by accessing the live video webcast of the event under "Events & Presentations" in the "Investors" section of the Company's website (www.karyopharm.com) beginning at 10:00 a.m. ET today. A copy of the presentation slides will be available under "Events & Presentations" in the "Investors" section of the Company's website after the event. The information contained in, or that can be accessed through the Company's website, is not a part of this filing.

The information in this Item 7.01 shall not be deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall such information be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing.

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