Certain Ordinary Shares of Keymed Biosciences Inc. are subject to a Lock-Up Agreement Ending on 7-JUL-2022. These Ordinary Shares will be under lockup for 365 days starting from 7-JUL-2021 to 7-JUL-2022. Details: Pursuant to the Hong Kong Underwriting Agreement, each of the Controlling Shareholders has undertaken to the Company, the Joint Sponsors, the Joint Global Coordinators, the Joint Bookrunners, the Hong Kong Underwriters that, without the prior written consent of the Joint Sponsors and the Joint Global Coordinators and unless in compliance with the requirements of the Listing Rules: (a) he/she/it will not, and will procure each of the Controlling Shareholders will not, at any time during the First Six-Month Period: (i) offer, pledge, charge, sell, contract or agree to sell, mortgage, charge, hypothecate, lend, grant or sell any option, warrant, contract or right to purchase, grant, or purchase any option, warrant, contract or right to sell, grant or agree to grant any option, right or warrant to purchase or subscribe for, lend or otherwise transfer or dispose of or create an Encumbrance over, either directly or indirectly, conditionally or unconditionally, any Shares or other securities of the Company or any interest in any of the foregoing (including, but not limited to, any securities that are convertible into or exchangeable or exercisable for, or that represent the right to receive, or any warrants or other rights to purchase, any Shares or other securities of the Company) beneficially owned by him/her/it as of the Listing Date (the “Locked-up Securities”); (ii) enter into any swap or other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of, any Locked-up Securities; (iii) enter into any transaction with the same economic effect as any transaction as described (i) and (ii) above; or (iv) offer to or contract to or agree to or publicly disclose that it will or may enter into any transaction as described in (i), (ii), and (iii) above, in each case, whether any of the transaction as described in (i), (ii), and (iii) above is to be settled by delivery of such Shares or such other securities of Company or in cash or otherwise (whether or not the settlement or delivery of such Shares or other securities will be completed within the First Six-Month Period); (b) he/she/it will not, and will procure each of the Controlling Shareholders will not, during the Second Six-Month Period, enter into any transaction described in (a)(i), (a)(ii) or (a)(iii) above in respect of any Locked-up Securities or offer to or agree to or contract to or publicly announce any intention to enter into any such transaction if, immediately following such transaction or upon the exercise or enforcement of any option, right, interest or Encumbrance pursuant to such transaction, he/she/it would cease to be a controlling shareholder (as defined under the Listing Rules) of the Company. Pursuant to the Lock-up Undertakings, the Pre-IPO Investors are subject to lock-up arrangements for a period of 180 days after the Listing Date.