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    9939   KYG5273B1077

KINTOR PHARMACEUTICAL LIMITED

(9939)
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Kintor Pharmaceutical : VOLUNTARY ANNOUNCEMENT FIRST PATIENT ENROLMENT FOR THE COVID-19 STUDY OF PROXALUTAMIDE WITH APPLIED BIOLOGY

08/21/2020 | 09:44am EDT

Hong Kong Stock Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement.

開 拓 藥 業 有 限 公 司 *

KINTOR PHARMACEUTICAL LIMITED

(Incorporated in the Cayman Islands with limited liability)

(Stock code: 9939)

VOLUNTARY ANNOUNCEMENT

FIRST PATIENT ENROLMENT FOR THE COVID-19 STUDY OF

PROXALUTAMIDE WITH APPLIED BIOLOGY

This is a voluntary announcement made by Kintor Pharmaceutical Limited (the "Company" and together with its subsidiaries, the "Group"). Reference is made to the announcement dated 12 July 2020 (the "Announcement") on the Research Agreement between Applied Biology, Inc. ("Applied Biology") and the Company to conduct research for Proxalutamide (GT0918) as a treatment for the coronavirus disease ("COVID-19") (the "Clinical Trial"). Unless otherwise defined herein, the capitalised terms shall have the same meaning as those defined in the Announcement.

The board (the "Board") of directors (the "Directors") of the Company is pleased to announce that on 20 August 2020, the Clinical Trial (ClinicalTrials.gov identifier: NCT04446429) has recorded the first patient enrolment in Brazil.

The Clinical Trial is a prospective, interventional, placebo controlled, double-blinded, randomised parallel assignment study exploring the anti-androgen treatment for COVID-19. The Clinical Trial is consisted of two experimental arms of Dutasteride plus standard care (the "Dutasteride Arm") and Proxalutamide plus standard care (the "Proxalutamide Arm") and one active comparator arm of placebo plus standard care (the "Controlled Arm"). Ivermectin + azithromycin are used as standard care given there has been no approved medication for coronavirus patients. For the purpose of exploring the possible protective role of anti-androgens in COVID-19 infections, 381 male study subjects aged 50 years old or above and present with androgenetic alopecia are estimated to be enrolled in the Clinical Study with 127 patients in each of the Dutasteride Arm, the Proxalutamide Arm and the Controlled Arm, respectively. It is estimated that the Clinical Trial will complete by the end of January 2021.

1

Proxalutamide (GT0918) is the Group's lead drug candidate and is in phase III clinical trials in China for metastatic castration-resistant prostate cancer ("mCRPC") with a targeted submission of new drug application in 2020. It is also undergoing phase II clinical trials for mCRPC in the United States. Proxalutamide (GT0918) is a potential best-in-class small molecule AR antagonist for the treatment of mCRPC based on well-researched AR mechanism and has a novel chemical structure that enables it to down regulate AR expression.

The Company is closely monitoring the progress of the Clinical Trial and will publish further announcement(s) to provide additional information when necessary.

By order of the Board

KINTOR PHARMACEUTICAL LIMITED

Dr. Youzhi TONG

Executive Director

Hong Kong, 21 August 2020

As of the date of this announcement, the executive Director is Dr. Youzhi Tong; the non-executive Directors are Dr. Chuangxing Guo, Mr. Gang Lu, Mr. Jie Chen, Dr. Bing Chen and Mr. Wei Zhang; and the independent non-executive Directors are Dr. Michael Min Xu, Dr. John Fenyu Jin and Mr. Wallace Wai Yim Yeung.

  • For identification purpose only

2

Disclaimer

Kintor Pharmaceutical Ltd. published this content on 21 August 2020 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 21 August 2020 13:44:24 UTC


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Sales 2022 1 100 M 163 M 163 M
Net income 2022 -59,4 M -8,80 M -8,80 M
Net cash 2022 401 M 59,4 M 59,4 M
P/E ratio 2022 -128x
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Capitalization 7 670 M 1 136 M 1 136 M
EV / Sales 2022 6,61x
EV / Sales 2023 2,60x
Nbr of Employees 316
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Managers and Directors
You Zhi Tong Chairman & Chief Executive Officer
Yan Lu CFO, Joint Secretary & Executive Director
Xunwei Dong Chief Medical Officer
Liandong Ma VP & Head-Research & Development
Qun Lu Chief Technology Officer
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