Certain Commom Stock of Krystal Biotech, Inc. are subject to a Lock-Up Agreement Ending on 28-FEB-2022. These Commom Stock will be under lockup for 90 days starting from 30-NOV-2021 to 28-FEB-2022.

Details:
The directors and executive officers have entered into lock-up agreements with the representatives prior to the commencement of this offering pursuant to which they have agreed for a period of 90 days, without the prior written consent of Goldman Sachs & Co. LLC, BofA Securities, Inc. and Cowen Company, LLC and William Blair & Company L.L.C. and subject to certain limited exceptions, not to (i) offer, sell, contract to sell, pledge, grant any option to purchase, lend or otherwise dispose of any shares of common stock, or any options or warrants to purchase any shares of common stock, or any securities convertible into, exchangeable for or that represent the right to receive shares of the common stock (such options, warrants or other securities, collectively, “Derivative Instruments”), including without limitation any such shares or Derivative Instruments owned as of the date of this prospectus supplement or hereafter acquired, (ii) engage in any hedging or other transaction or arrangement (including, without limitation, any short sale or the purchase or sale of, or entry into, any put or call option, or combination thereof, forward, swap or any other derivative transaction or instrument, however described or defined) which is designed to or which reasonably could be expected to lead to or result in a sale, loan, pledge or other disposition (whether by a director or executive officer or someone other than a director or executive officer), or transfer of any of the economic consequences of ownership, in whole or in part, directly or indirectly, of any shares of the common stock or Derivative Instruments, whether any such transaction or arrangement (or instrument provided for thereunder) would be settled by delivery of common stock or other securities, in cash or otherwise or (iii) otherwise publicly announce any intention to engage in or cause any action or activity described in clause (i) above or transaction or arrangement described in clause (ii) above.