Item 5.07 Submission of Matters to a Vote of Security Holders.

On May 20, 2022, Krystal Biotech, Inc. (the "Company") held its 2022 Annual Meeting of Stockholders (the "Annual Meeting"). Set forth below are the matters acted upon at the Annual Meeting and the final voting results on each matter.

Proposal One: Election of Class II Directors

The Company's stockholders elected Daniel S. Janney, Dino A. Rossi, and E. Rand Sutherland as members of the Company's Board of Directors as Class II directors for a three-year term. The results of the vote were as follows:


       Nominee            Votes For       Votes Withheld        Broker Non-Votes
 Daniel S. Janney         16,477,053         3,359,641             2,292,505
 Dino A. Rossi            16,642,737         3,193,957             2,292,505
 E. Rand Sutherland       19,828,360           8,334               2,292,505


Proposal Two: Ratification of Appointment of Independent Registered Public Accounting Firm

The Company's stockholders ratified the appointment of Mayer Hoffman McCann P.C. as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2022. The results of the vote were as follows:


 Votes For        Votes Against       Abstentions
 21,966,753           3,157             159,289


Proposal Three: Non-Binding, Advisory Vote On Named Executive Officer Compensation

The Company's stockholders approved, on an advisory (non-binding) basis, the compensation of the Company's named executive officers for the fiscal year ended December 31, 2021, as disclosed in the Company's proxy statement for the Annual Meeting pursuant to the compensation disclosure rules of the Securities and Exchange Commission. The results of the vote were as follows:


 Votes For        Votes Against       Abstentions        Broker Non-Votes
 16,441,350         3,335,424            59,920             2,292,505



Proposal Four: Non-Binding, Advisory Vote on the Frequency of Advisory Votes on Named Executive Officer Compensation

The Company's stockholders recommended, on an advisory (non-binding) basis, every year as the frequency of future advisory votes on the compensation of the Company's named executive officers. The results of the vote were as follows:


  Every Year       Two Years      Three Years       Abstentions
  19,579,383         1,326          196,689            59,296


Based on these voting results, and the recommendation of the Company's Board of Directors that was included in the proxy statement for the Annual Meeting, the Company has determined that it will hold future advisory votes on the compensation of the Company's named executive officers on an annual basis until the next stockholder advisory vote on the frequency of future advisory votes on the compensation of the Company's named executive officers.

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