'People living with Parkinson's and their families want the moments that matter to them, which may become difficult when they experience 'off' episodes,' said
The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness, constipation, nausea, hallucinations, and problems sleeping (insomnia). These are not all the possible side effects of NOURIANZ. Please see Important Safety Information below.
Simplifying a complex scientific story
Adenosine and dopamine are naturally occurring chemicals in the brain that normally work together in balance to control movement. However, in Parkinson's disease there is too little dopamine activity and too much adenosine activity. This imbalance can cause PD symptoms, such as difficulty moving.
Many treatments for PD, like levodopa/carbidopa, focus on increasing dopamine activity. But as the disease progresses, patients can experience 'off' episodes when the full effects of levodopa/carbidopa start to wear off, allowing Parkinson's symptoms to return.
To help explain this to patients, new content features a simple gas/brake analogy, brought to life through illustrations and dynamic video animation, to spotlight the role of dopamine and adenosine in Parkinson's disease and how NOURIANZ is believed to work. Visitors to the NOURIANZ website can also hear how a patient and his care partner are navigating their Parkinson's journey, including how they recognized and addressed 'off' episodes together with their doctor. To help patients navigate their PD journey, additional resources are also available on the site for download.
The new content is part of a continuing effort to educate patients and healthcare professionals through a mix of personal, print, and digital communications and virtual programming. Physicians can visit the NOURIANZ website for healthcare professionals to learn more about the role of adenosine and NOURIANZ clinical data, and to access tools to aid in patient education.
What is NOURIANZ?
NOURIANZ (istradefylline) is a prescription medicine used with levodopa and carbidopa to treat adults with Parkinson's disease who are having 'off' episodes. It is not known if NOURIANZ is safe and effective in children.
Important Safety Information
Before taking NOURIANZ, tell your healthcare provider about all your medical conditions, including if you: have a history of abnormal movement (dyskinesia) have reduced liver function smoke cigarettes are pregnant or plan to become pregnant. NOURIANZ may harm your unborn baby are breastfeeding or plan to breastfeed. It is not known if NOURIANZ passes into breast milk. You and your healthcare provider should decide if you will take NOURIANZ or breastfeed
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
NOURIANZ and other medicines may affect each other causing side effects. NOURIANZ may affect the way other medicines work, and other medicines may affect how NOURIANZ works.
NOURIANZ may cause serious side effects, including: uncontrolled sudden movements (dyskinesia). Uncontrolled sudden movements is one of the most common side effects. hallucinations and other symptoms of psychosis. NOURIANZ can cause abnormal thinking and behavior, including being overly suspicious or feeling people want to harm you (paranoid ideation) believing things that are not real (delusions) seeing or hearing things that are not real (hallucinations) confusion increased activity or talking (mania) disorientation aggressive behavior agitation delirium (decreased awareness of things around you) unusual urges (impulse control or compulsive behaviors). Some people taking NOURIANZ get urges to behave in a way unusual for them. Examples of this are unusual urges to gamble, increased sexual urges, strong urges to spend money, binge eating, and the inability to control these urges.
If you or your family notices that you are developing any new or unusual symptoms or behaviors, talk to your healthcare provider.
The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness, constipation, nausea, hallucinations, and problems sleeping (insomnia).
These are not all the possible side effects of NOURIANZ.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
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