Item 1.01 Entry into a Material Definitive Agreement.

On November 19, 2010, Laboratory Corporation of America Holdings (the "Company") entered into an Indenture with U.S. Bank National Association, as trustee (the "Indenture"). On May 26, 2021, the Company entered into supplemental indentures to the Indenture under which the Company issued $1,000,000,000 in debt securities, consisting of $500,000,000 aggregate principal amount of 1.550% Senior Notes due 2026 (the "2026 Notes") and $500,000,000 aggregate principal amount of 2.700% Senior Notes due 2031 (the "2031 Notes" and, together with the 2026 Notes, the "Notes").

The 2026 Notes were issued pursuant to the Fifteenth Supplemental Indenture dated as of May 26, 2021, under the Indenture (the "2026 Notes Supplemental Indenture") and the 2031 Notes were issued pursuant to the Sixteenth Supplemental Indenture dated as of May 26, 2021, under the Indenture (the "2031 Notes Supplemental Indenture, and together with the 2026 Notes Supplemental Indenture, the "Supplemental Indentures").

The Notes were issued in a public offering pursuant to the Company's effective shelf registration statement on Form S-3 (File No. 333-234633) and the base prospectus included in that registration statement as supplemented by the final prospectus supplement dated May 12, 2021, as filed May 14, 2021 pursuant to Rule 424(b)(5) under the Securities Act of 1933, as amended (the base prospectus, as supplemented by the prospectus supplement, the "Prospectus"). The terms of the Indenture, the Supplemental Indentures, and the Notes are described in the section of the Prospectus entitled "Description of Debt Securities," as supplemented by the section entitled "Description of the Notes," and those sections of the Prospectus are incorporated in this Form 8-K by reference.

The Company expects that the net proceeds from the offering of the Notes will be approximately $989.3 million after deducting underwriting discounts and other estimated expenses of the offering. The Company expects to use the net proceeds to redeem, prior to maturity, its outstanding 3.20% Senior Notes due February 1, 2022 and 3.75% Senior Notes due August 23, 2022.

A copy of the Indenture is incorporated by reference as Exhibit 4.1 to this Report. A copy of each of the Supplemental Indentures, including the forms of the 2026 Notes and the 2031 Notes as Exhibit A thereto, are filed herewith as Exhibit 4.2 and Exhibit 4.3, respectively.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.





4.1       Indenture, dated as of November 19, 2010, between the Company and U.S.
        Bank National Association, as trustee (incorporated by reference to
        Exhibit 4.1 to the Company's Current Report on Form 8-K filed on
        November 19, 2010)

4.2       Fifteenth Supplemental Indenture, dated as of May 26, 2021, between the
        Company and U.S. Bank National Association, as trustee, including the form
        of the 2026 Notes

4.3       Sixteenth Supplemental Indenture, dated as of May 26, 2021, between the
        Company and U.S. Bank National Association, as trustee, including the form
        of the 2031 Notes

104     Cover Page Interactive Data File (embedded within the Inline XBRL
        document)

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