Lantheus Holdings, Inc. Announces First Patient Dosed in Phase 2 Clinical Trial of NM-01 to Monitor PD-L1 Expression in Non-Small Cell Lung Cancer Patients

Lantheus Holdings, Inc. announced first patient has been dosed in a phase 2 trial evaluating NM-01, its proprietary technetium 99m SPECT imaging agent used to assess PD-L1 expression in cancer cells, for its potential to identify patients will respond to checkpoint inhibitor therapies. The PELICAN trial (NCT04992715) is an open-label, single-arm trial in non-small cell lung cancer (NSCLC) patients. The primary endpoint is the assessment of PD-L1 expression in primary tumor and metastatic lesions by NM-01 compared to immunohistochemistry.

Other objectives will look at quantifying intra- and inter-tumoral heterogeneity of PD-L1 expression by NM-01, as well as establishing correlation with other diagnostic procedures. The trial is being conducted by Lantheus' partner NanoMab Technology Limited (NanoMab) at King's College London. Lantheus licensed NM-01 from NanoMab in 2019.