Lysogene provides a medical update. First, Lysogene has dosed the first patient in France with LYS-GM101 investigational gene therapy at the Armand Trousseau Hospital (AP-HP). This is the third patient treated with LYS-GM101 in the global adaptative-design clinical trial (NCT04273269) in children with GM1 gangliosidosis.

The enrollment of the 4th patient of the safety cohort is ongoing, following which Lysogene will initiate the treatment of the 12 patients of the efficacy confirmatory cohort. Second, Lysogene has appointed a seasoned Chief Medical Officer, Dr. Marie Trad, effective February 1st, 2022. With over thirty years of clinical and pharmaceutical development experience in the field of neurologic diseases, Dr. Marie Trad, M.D., brings her in-depth knowledge and expertise to lead Lysogene's gene therapy pipeline global clinical development from early stages throughout the lifecycle up to post-marketing stages.

Dr. Trad is a board-certified neurologist and a qualified neuroradiologist from the Pierre and Marie Curie University, Paris, France. After over a decade of clinical practice, Dr. Trad joined the bio-pharmaceutical industry in 2000 in varied senior strategic roles, both in Bio-Pharma and CROs. Her multivalent skills and significant experience in neurology, as well as her strong relationship with specialized clinical trial centers and key opinion leaders, makes Dr. Trad a strategic addition to Lysogene's team.

Lastly, Lysogene will make two oral presentations at the WORLDSymposium™ 2022, which will take place from 7 to 11 February 2022 in San Diego, USA. Dr. Ralph Laufer, Chief Scientific Officer of Lysogene, will present new biomarker data from the ongoing AAVance clinical trial in children with MPS IIIA. Karen Aiach, Chairman and CEO of Lysogene will present preliminary safety data from the ongoing adaptive clinical study in children with GM1 gangliosidosis.