Medicenna Therapeutics Corp. announced the initiation of dosing of patients in the Phase 1/2 ABILITY (A Beta-only IL-2 ImmunoTherapY) study of MDNA11, the Company's selective, long-acting and novel IL-2 super-agonist. The study is designed to assess the safety, PK, PD, and anti-tumor activity of various doses of intravenously administered MDNA11 in patients with advanced solid tumors and includes an MDNA11 monotherapy arm, as well as a combination arm designed to evaluate MDNA11 with a checkpoint inhibitor. The ABILITY study is currently enrolling patients at clinical trial sites in Australia with expansion to additional sites planned in the United States, Canada, and the United Kingdom. Medicenna expects the remaining regulatory submissions for these jurisdictions to be completed this calendar year. The ABILITY study plans to enroll at least 80 patients with advanced, relapsed, or refractory solid tumors. Patients will receive MDNA11 via intravenous administration in an out-patient setting. Following establishment of the recommended dose and treatment schedule, Medicenna plans to enroll expansion cohorts of patients with renal cell carcinoma and melanoma along with a cohort of patients with other solid tumors in monotherapy and combination settings. A preliminary update on safety, PK/PD, and biomarker data from early cohorts of patients enrolled in the dose escalation phase of the ABILITY Study this year is expected by the end of calendar 2021. Preliminary efficacy updates from the study are expected at various times during calendar 2022.