Medtronic plc announced final findings from a randomized, international, multi-center study that confirmed the effectiveness of the GI Genius™ intelligent endoscopy module, which uses AI as an aid in detecting colorectal polyps during colonoscopy, potentially helping to prevent colorectal cancer. The study, published on March 15 in Gastroenterology, the official medical journal of the American Gastroenterological Association, found that the use of GI Genius in conjunction with colonoscopy significantly decreases the miss rate (2x) of colorectal polyps and adenomas compared to standard colonoscopy. In colonoscopies performed as part of the study, adenoma miss rate (AMR) was significantly lower when GI Genius was used as compared to a non-AI-assisted colonoscopy (15.5% vs 32.4%; p-value <0.001).

These findings demonstrate that the use of GI Genius during colonoscopy significantly decreases the miss rate of both adenomas and polyps, further confirming the benefit GI Genius adds to colonoscopy procedures.1 The study further found that false negative rates, when a GI Genius-assisted colonoscopy detected adenoma(s) after an initial standard colonoscopy did not, were much lower than that of non-AI-assisted colonoscopies (6.8% vs. 29.6%). In this study, a false negative indicates patients with an initial standard colonoscopy where no adenoma was detected were subsequently found to have at least one adenoma during a second AI-assisted colonoscopy.

The findings confirm topline results of the DETECT study from November 2021 that both AMR and polyp miss rate (PMR) significantly improve when GI Genius is used during colonoscopy. The study was funded by Cosmo Pharmaceuticals, the developer and manufacturer of Medtronic's GI Genius system.