Mendus AB (publ) announced the upcoming presentation of first clinical data from the ongoing ALISON Phase I trial evaluating safety and feasibility of its maintenance immunotherapy product candidate DCP-001 in ovarian cancer. The initial data demonstrates that DCP-001 was safe and well-tolerated, confirming the benign safety profile of DCP-001 observed in multiple completed and ongoing clinical trials. This supports its suitability as a maintenance therapy and justifies continued development of this novel immunotherapy concept in ovarian cancer, the deadliest gynaecological cancer due to its high recurrence rate.

The presentation at the ESGO Congress will also include new preclinical data demonstrating the synergistic effects of combining DCP-001 vaccination with intratumoral immune priming. This novel therapeutic strategy of combining local and systemic intervention benefits from Mendus' unique expertise in both areas and resulted in a very potent suppression of tumor growth, including complete tumor regressions in a humanized mouse model for ovarian cancer.