By Colin Kellaher
Merck & Co. on Wednesday reported mixed results from a pair of Phase 3 studies of its blockbuster cancer drug Keytruda.
The Kenilworth, N.J., drugmaker said a study evaluating Keytruda in combination with standard of care chemotherapy showed a statistically significant and clinically meaningful improvement in overall survival versus chemotherapy alone for the first-line treatment of patients with advanced or unresectable biliary tract cancer.
However, Merck said it is stopping a study of Keytruda in combination with enzalutamide and androgen-deprivation therapy in patients with metastatic hormone-sensitive prostate cancer due to futility. The company said an interim analysis showed the combination didn't demonstrate an improvement in overall survival or radiographic progression-free survival, the trial's dual primary endpoints.
Merck, which is studying Keytruda in a raft of trials across a wide variety of cancers and treatment settings, said it plans to submit the study results in biliary tract cancer to regulatory authorities.
Keytruda, a cancer drug that harnesses a patient's immune system to fight tumors, is approved in dozens of indications around the world and had sales of nearly $15.5 billion for the first nine months of 2022.
Write to Colin Kellaher at colin.kellaher@wsj.com
(END) Dow Jones Newswires
01-25-23 0729ET