Merus N.V. announced interim efficacy data as of an April 12, 2022 data cutoff date, from the phase 1/2 eNRGy trial and Early Access Program (EAP) of the bispecific antibody Zeno in patients with NRG1+ cancer presented virtually by Lead Author, Dr. Alison Schram of Memorial Sloan Kettering Cancer Center (MSKCC) at the 2022 ASCO Annual meeting. Key findings of the presentation include: As of April 12, 2022, 110 patients were treated with Zeno; Efficacy was assessed in 79 evaluable patients with measurable disease having the opportunity for 6 months or more follow-up and who met the criteria for the primary analysis population; Median age was 59 years (range of 22-84); 59% were female; Median number of prior lines of systemic therapy was 2, (range of 0-8); Qualifying NRG1 fusions included 26 distinct fusion partners; ORR per RECIST criteria as assessed by investigator was 34% (95% Cl; 24%-46%) across multiple tumor types: PDAC ORR 42% (8/19) and NSCLC ORR 35% (16/46); Tumor shrinkage was observed in 70% of patients; Median time to response was 1.8 months, and median duration of exposure was 6.3 months; Median duration of response was 9.1 months, and 20/83 patients were continuing treatment as of the cutoff date; Strong safety profile with a low incidence of Grade 3 or higher treatment-related adverse events, including low rates of severe gastrointestinal and dermatologic toxicity, without clinically significant cardiotoxicity.