Item 5.02 Departure of Directors or Certain Officers; Election of Directors;


          Appointment of Certain Officers; Compensatory Arrangements of Certain
          Officers.


(b) On October 28, 2021, it was determined that Daniel R. Faga would cease
serving as the Executive Vice President, Chief Operating Officer and principal
financial officer of Mirati Therapeutics, Inc. (the "Company") and that Joseph
Leveque would cease serving as the Company's Executive Vice President and Chief
Medical Officer, effective as of November 1, 2021.

(c) Vickie Reed, the Company's Chief Accounting Officer, will assume the role of
principal financial officer effective as of November 1, 2021. There will be no
change to Ms. Reed's compensation arrangements with the Company as a result of
her appointment. There are no family relationships between Ms. Reed and any of
the Company's current or former directors or executive officers. Ms. Reed is not
a party to any transaction that would require disclosure under Item 404(a) of
Regulation S-K promulgated under the Securities Act of 1933, as amended.

Item 7.01 Regulation FD Disclosure.




The events described under Item 5.02(b) are part of a restructuring of the
Company's executive leadership team, as described in a statement posted on the
Company's corporate web site on November 1, 2021.
http://ir.mirati.com/press-releases/press-release-details/2021/Statement-Updates-to-Mirati-Therapeutics-Executive-Leadership-Team

The information in this Item 7.01 shall not be deemed "filed" for the purposes
of or otherwise subject to the liabilities under Section 18 of the Securities
Exchange Act of 1934, as amended (the "Exchange Act"). Unless expressly
incorporated into a filing of the Company under the Securities Act or the
Exchange Act, the information contained in this Item 7.01 shall not be
incorporated by reference into any Company filing, whether made before or after
the date hereof, regardless of any general incorporation language in such
filing.

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