Ivectosol™ being tested to target certain cancers to pursue novel human intratumoral injection and intravenous infusion
Summary
- MVMD files cancer patent for direct intratumoral injection, intravenously, infusions or instillations as adjuvants for broad chemotherapeutic to immunotherapeutic cancer regimens.
- The Company is proceeding with three separate pre-clinical trials with specialized third-party cancer CROs: (1) triple-negative breast cancer; (2) metastatic melanoma; and (3) Lewis Lung Carcinoma as a proxy for non-small cell lung carcinoma.
- The Company believes the research will have near-immediate application to direct human trials based on safety and efficacy of ivermectin.
"The extensive research supporting the drug ivermectin as effective in the inhibition of proliferation, metastasis, and angiogenic activity in a variety of cancers, and as an initiator of immunogenic cell death, is overwhelming," stated
Leading up to the implementation of pre-clinical trial cancer research, MVMD has been extensively researching the drug ivermectin, including its impact on cancer, and has included numerous abstracts at the end of this media release. All of the research articles cited involve either existing oral ivermectin in a murine model or the in-vitro testing of ivermectin utilizing organic solvents for solubilization that would be prohibited in a human intravenous or intratumoral administration.
As cited by
MVMD filed its cancer adjuvant patent, Novel Injectable, Infusable, Instillable Ivermectin Adjuvant for Cancer Therapies for its solubilized ivermectin (Ivectosol™). The patent-pending adjuvant utilizes the Company's advances in macrocyclic lactone solubility to consider Ivectosol™ as a viable adjuvant for numerous cancer therapies. MVMD's solubility technology applied to the ivermectin drug is the only form in the world that uses strictly excipients that are currently approved by the
The pre-clinical trials that are being conducted are designed to prove the utility of Ivectosol™ to synergize and improve various cancer regimens currently in use and as a potent enhancer of current immunotherapies and chemotherapies for difficult to treat cancers.
Study One: Triple-negative breast cancer
- Study will test the effectiveness of Ivectosol™ combined with checkpoint inhibitor that would be equivalent to either OPDIVO or Keytruda for disease progression and complete response rate
- Arms in the study will look at single checkpoint inhibitor, oral IVM + checkpoint inhibitor and intratumoral IVM + checkpoint inhibitor
- Estimated initial readouts/analysis – 2nd week of June, 2021
- Complete readout with flow cytometry and statistical evaluation estimated mid-July, 2021 with possible abstract submission in August, 2021
Study Two: Metastatic melanoma
- Study will test the effectiveness of Ivectosol™ intratumoral combined with checkpoint inhibitor for disease progression and complete response rate
- Arms in the study will look at single checkpoint inhibitor, oral IVM + checkpoint inhibitor and intratumoral IVM + checkpoint inhibitor
- Estimated initial readouts by end of June, 2021
- Complete readout with flow cytometry and statistical evaluations estimated end of July, 2021 with possible abstract submission in August, 2021
Study Three: Lewis lung carcinoma as a proxy for non-small cell lung carcinoma
- Study will test the effectiveness of Ivectosol™ intratumorally combined with checkpoint inhibitor for disease progression and complete response rate
- Arms in the study will look at single checkpoint inhibitor, oral IVM + checkpoint inhibitor, intratumoral IVM + checkpoint inhibitor, navalbine + intratumoral IVM
- Estimated initial readouts by end of June, 2021
- Complete readouts with flow cytometry and statistical evaluation estimated by end of July, 2021 with possible abstract submission in August, 2021
All three studies will assess tumor growth and metastases through bioluminescence imaging, a non-invasive optical imaging modality designed to visualize and quantify bioluminescent signal in tissues. The Company is also actively pursuing a pre-clinical trial for bladder cancer and is currently assessing the best option to proceed through the evaluation of CRO proposals.
"Ivermectin is a
According to the
Reference Sources:
*
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/
**
https://www.who.int/news-room/fact-sheets/detail/cancer
***
https://www.worldcancerday.org/financial-and-economic-impact
Cancer Research Sources:
NOTE: All of the articles cited below involve either oral ivermectin in a murine model or the in-vitro testing of ivermectin utilizing organic solvents for solubilization that would be prohibited in a human intravenous or intertumoral administration.
Ivermectin, a potential anticancer drug derived from an anti-parasitic drug.
Authors:
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/
Ivermectin as an inhibitor of cancer stem-like cells.
Authors:
Molecular Medicine Reports.
Link: https://www.spandidos-publications.com/mmr/17/2/3397
The Anti-Cancer Effects of Anti-Parasite Drug Ivermectin in Ovarian Cancer
Authors: Xianquan Zhan, Na Li
IntechOpen.
Link: https://www.intechopen.com/online-first/the-anti-cancer-effects-of-anti-parasite-drug-ivermectin-in-ovarian-cancer
Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in Oesophageal squamous cell carcinoma.
Authors:
Link: https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.15195
Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer
Authors:
NPJ Breast Cancer, Volume 7, Article number: 22 (2021)
Link: https://www.nature.com/articles/s41523-021-00229-5
The Multitargeted drug Ivermectin: from an antiparasitic agent to a repositioned cancer drug.
Authors:
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/
Continuous high-dose ivermectin appears to be safe in patients with acute myelogenous leukemia and could inform clinical repurposing for COVID-19 infection.
Authors:
Leukemia & Lymphoma: 2020, Volume 16, Issue 10
Link: https://www.tandfonline.com/doi/full/10.1080/10428194.2020.1786559
Repurposing anthelmintic agents to eradicate resistant leukemia.
Authors:
Link: https://www.nature.com/articles/s41408-020-0339-9.pdf
The Company is not making any claims that Ivectosol™ is an effective treatment for any form of cancer, or any other medical condition, at this time.
ABOUT
MVMD's proposition for delivering Quicksome™ formulations that have rapid onset, high bioavailability, low variability and precision dosing is core to the Company's success across key health and wellness categories. Consistent with its vision towards "Helping People Live Their Best Life", MVMD applies its Quicksome™ and Quicksol™ technologies to its ground-breaking work for advanced delivery of vaccines and pharmaceutical drugs as well as the development of products for pain management, weight loss, energy, focus, sleep, anxiety, and more.
The Company's patented Quicksome™ desiccation technology utilizes advanced liposomes and other stabilizing molecules to encapsulate and formulate active ingredients into highly efficient product formats that are consumed orally. The result is a new generation of product formulations that are capable of delivering vaccines, drugs and nutraceuticals into the body faster, with greater impact, efficiency and accuracy.
The Company's patented Quicksol™ solubilization technology covers all highly solubilized macrocyclic lactones (including the drugs Ivermectin and Selamectin). MVMD's solubility technology applied to the Ivermectin drug is the only form in the world that only uses excipients that are currently approved by the
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Certain statements contained in this news release may constitute forward-looking information. Forward-looking information is often, but not always, identified by the use of words such as "anticipate", "plan", "estimate", "expect", "may", "will", "intend", "should", and similar expressions. Forward-looking information involves known and unknown risks, uncertainties and other factors that may cause actual results or events to differ materially from those anticipated in such forward-looking information.
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The Company is making forward-looking statements, including but not limited to its planned pre-clinical trials with third-party cancer CROs in triple-negative breast cancer, metastatic melanoma, and lung carcinoma.
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